Association between VEGF gene and residual ridge resorption of mandible in Korean population
한국인에서 VEGF 유전자와 하악 잔존치조제 흡수와의 연관성
Dept. of Dental Science/석사
Objective: To find the genetic association between SNPs and haplotypes of VEGF gene and residual ridge resorption in a Korean population. Materials and Methods: Eighty-nine subjects (71.63 ± 9.76 years) One hundred twenty subjects (70.93 ± 9.28 years)120 subjects(?? +_ ?? years) who werewas treated in Dental clinic of Yonsei university One hundred nineteen subjects (70.93 ± 9.28 years) with partially or completely edentulous mandible were recruited. Mandibular bone height was measured following the protocol of the American College of Prosthodontists. Three variants, rs1570360, rs25648, and rs3025039 in VEGF were used as tag-SNPs and genotyped for the whole Korean population 1population. Student’s t-test and ANOVA were used for statistical analysis to examine association between SNPs and height of residual ridge. Haplotypes with frequency rates over 0.05 was selected and was analyzed with same statistical methods. Results: Three tag SNPs from VEGF gene were tested and haplotype G-C-C, the most prevalent type, A-C-C, the second prevalent type, showed statistically significant association with the process of residual ridge resorption in the recessive dominant group (P = 0.020) (P=0.042). Conclusion: Haplotype I, the most prevalent type, Haplotype A-C-C, the second prevalent type, were associated with lessseverely atrophied mandibular bone in recessive dominant groups. Other haplotypes might be functionally inferior to type I A-C-C in angiogenesis and adaptation to hypoxic environment. Results of this study may be useful in developing novel genetic diagnostic tests and identifying Koreans susceptible to developing excessive jawbone atrophy after dental extraction.