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A comparative analysis of hepatocellular carcinoma after hepatic resection in young versus elderly patients

Other Titles
 젊은 연령 및 고령 환자에서 발생한 원발성 간암의 간절제술후 성적비교 연구 
Issue Date
2013
Description
Dept. of Medicine/석사
Abstract
Purpose: The aim of this study was to investigate the clinical outcomes after surgical treatment of hepatocellular carcinoma (HCC) in the elderly patients compared with younger patients. Methods: Clinicopathological data and treatment outcomes in 61 elderly (≥70 years old) and 90 younger (≤40 years old) patients with HCC who underwent curative liver resection between 2000 and 2010 were retrospectively collected and compared using various parameters. Results: The older HCC group was more likely to have hepatitis C virus and non-B non-C hepatitis virus infection, higher values of indocyanine green retention at 15 minutes (ICGR)15, more preoperative co-morbidities, and more postoperative complications. There were no significant differences in intraoperative parameters and pathologic features. The recurrence rate, overall survival and disease-free survival rates were similar amongst the two groups. The only independent prognostic factor of overall survival was postoperative complications. Conclusion: Our findings suggest that age by itself does not have an adverse effect on operative outcomes, including long-term prognosis. For young and elderly HCC patients, hepatic resection is a safe and effective treatment.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/134501
Appears in Collections:
2. 학위논문 > 1. College of Medicine (의과대학) > 석사
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