Epigenetic regulation in the brain motor cortex following spinal cord injury
Dept. of Rehabilitation Medicine/석사
After spinal cord injury (SCI), functional and structural changes occur in multiple levels of the brain including the motor cortex. The underlying mechanism still remains unclear. The current study sought to investigate the alterations in the expression of the main regulators of neuronal development, survival and death, histone deacetylase (HDAC) related protein, brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF) and nerve growth factor (NGF) in the brain following thoracic contusive SCI in a mouse model.The BDNF levels were elevated significantly compared to no injury at 2 weeks post injury (p<0.05), but the BDNF levels were reduced compared to no injury group at 4, 8 weeks post injury. These reductions were not significant (p>0.05). The NGF levels were elevated at 2, 4 weeks and reduced at 8 weeks compared to no injury group, but these differences were not significant (p>0.05). The GDNF levels were elevated at 2 weeks and reduced at 4, 8 weeks compared to no injury group, but these differences were not significant (p>0.05). The difference of HDAC1 levels were not significant at 2, 4 and 8 weeks compared to no injury group (p>0.05).These results demonstrate time-dependent changes in the main regulator of neuronal cell survival and death in the whole brain.