Cited 0 times in

Correlations of DCE-MRI with morphologic, angiogenic, and molecular prognostic factors in rectal cancer

Title
Correlations of DCE-MRI with morphologic, angiogenic, and molecular prognostic factors in rectal cancer
Other Titles
직장암의 형태적, 혈관생성 및 분자 예후인자와 역동적 조영증강 자기공명영상과의 상관관계
Issue Date
2012
Publisher
Graduate school, Yonsei University
Description
Dept. of Medicine/박사
Abstract
PURPOSE: The purpose of this study was to investigate the correlations between parameters of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and prognostic factors in rectal cancer.MATERIALS AND METHODS: We studied 29 patients with rectal cancer who underwent DCE-MRI with a three Tesla scanner prior to surgery. Signal intensity on DCE-MRI was independently measured by two observers to test reproducibility. A time-signal intensity curve was generated, from which four semiquantitative parameters were calculated: steepest slope (SLP), time to peak (Tp), relative enhancement during a rapid rise (Erise), and maximal enhancement (Emax). Morphologic prognostic factors including T stage, N stage, and histologic grade were identified. Tumor angiogenesis was evaluated in terms of microvessel count (MVC), microvessel area (MVA), and expression of vascular endothelial growth factor (VEGF). As molecular factors, the mutation status of the K-ras oncogene and microsatellite instability were assessed. DCE-MRI parameters were correlated with each prognostic factor using bivariate correlation analysis. A p-value of <0.05 was considered significant.RESULTS: Erise was significantly correlated with N stage (r=-0.387 and -0.393, respectively for the two independent data), and Tp was significantly correlated with histologic grade (r=0.466 and 0.489, respectively). Emax was significantly correlated with MVC (r=-0.435 and -0.386, respectively). SLP (r=-0.532 and -0.535, respectively) and Erise (r=-0.511 and -0.446, respectively) were significantly correlated with MVA. No significant correlations were found between DCE-MRI parameters and T stage, expression of VEGF, K-ras mutation, or microsatellite instability.CONCLUSION: DCE-MRI may provide useful prognostic information in patients with rectal cancer.
URI

http://ir.ymlib.yonsei.ac.kr/handle/22282913/134394
Appears in Collections:
2. 학위논문 > 5. Others > 기타 학위논문
Yonsei Authors
사서에게 알리기
  feedback
Fulltext
교내이용자 서비스로 제공됩니다.
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse