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Clinical implication of right bundle branch block in hospitalized patients with acute heart failure : data from the Korean Heart Failure (KorHF) registry

Title
Clinical implication of right bundle branch block in hospitalized patients with acute heart failure : data from the Korean Heart Failure (KorHF) registry
Other Titles
한국 심부전 등록 사업 자료를 이용한 급성 심부전으로 입원한 환자에서 우각차단이 갖는 임상적 의의
Issue Date
2012
Publisher
Graduate School, Yonsei University
Description
Dept. of Medicine/석사
Abstract
Background:Conflicting data exist regarding the predictive value of bundle branch block (BBB) patterns for mortality in hospitalized patients with acute heart failure (AHF).Methods:Two thousand two hundred and two patients enrolled in the Korean Heart Failure (KorHF) Registry were analyzed to compare clinical outcomes among right BBB (RBBB, 5.4%), left BBB (LBBB, 4.9%), and no BBB (89.7%) on admission electrocardiogram. The primary composite endpoint was all-cause mortality or rehospitalization. The primary composite endpoint was all-cause mortality or rehospitalization.Results:During the median follow-up period of 572 days, the 3-year event rate of the composite endpoint was significantly higher in the patients with RBBB compared to those with LBBB or no BBB (65.1% vs. 49.9% vs. 49.3%, log-rank, p=0.004). Multivariate analysis demonstrated an increased risk of the composite endpoint for the patients with RBBB vs. LBBB (hazard ratio (HR)=2.57, p=0.001) and the patients with RBBB vs. no BBB (HR=1.91, p<0.001). In the reduced left ventricular ejection fraction (LVEF  40%), the risk of the composite endpoint was increased in the patients with RBBB vs. LBBB (for overall from HR 1.61, p=0.002 to HR=2.28, p=0.001).Conclusion: RBBB but not LBBB is a significant predictor of all-cause mortality or rehospitalization in hospitalized patients with AHF, especially with reduced LV systolic function.
URI

http://ir.ymlib.yonsei.ac.kr/handle/22282913/134390
Appears in Collections:
2. 학위논문 > 1. College of Medicine (의과대학) > 석사
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