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The association between BMI change and subcutaneous and visceral adiposity in adulthood : the Kangwha study

Other Titles
 BMI 변화가 초기 성인기의 내장지방과 피하지방에 미치는 영향에 관한 연구 
Authors
 이명하 
Issue Date
2012
Description
Dept. of Public Health/박사
Abstract
Background: Visceral fat is associated with metabolic syndrome, cardiovascular disease and type 2 diabetes, mainly through insulin resistance. Although the expansion of both subcutaneous and visceral fat contribute to metabolic disease, subcutaneous fat is considered to be a weaker risk factor, and in some cases has been reported to have a protective effect. We hypothesized that there might be critical periods for the prediction of adult subcutaneous and visceral fat mass by BMI changes in different phases in life. Objective: The objective of this study was (1) to investigate whether serial measurements of BMI from childhood can predict abdominal subcutaneous and visceral adipose tissue in adulthood (2) to examine whether BMI changes during different developmental periods (late childhood, adolescence, and young adult) is associated with adult abdominal subcutaneous and visceral adipose tissue in a different manner in a longitudinal follow-up study. Methods: The Kangwha Study is a community-based prospective cohort study started in 1986 in Kangwha County, South Korea. The study dataset included 14 measurements over a 24-year period from 247 (120 male and 127 female) participants who completed the 2010 examination and abdominal CT scan. All participants were 7 years old when the study began and were followed for the next 24 years.Results: Visceral adipose tissue in adults at age 30 is shown to be associated with BMI changes during all 3 developmental periods (late childhood, adolescence, and young adult) in both sexes. Subcutaneous adipose tissue in adult was associated with BMI changes during all 3 periods in male, whereas during adolescence and young adult in female. The magnitude of the association between BMI change and visceral adipose tissue were greater in female than in male, whereas the magnitude of the association between BMI change and subcutaneous adipose tissue were greater in male than in female.Conclusions: In conclusion, BMI changes during different periods show impact on subcutaneous and visceral fat mass in early adulthood throughout late childhood, adolescence, and young adult. The results suggest that BMI change in female had a greater impact on visceral fat than in male, whereas BMI change in male had a greater impact on subcutaneous fat than in female. These findings suggest that avoiding substantial BMI increases during different developmental periods might result in lower adult subcutaneous and visceral fat mass for health later in life.
Appears in Collections:
1. College of Medicine (의과대학) > Others (기타) > 3. Dissertation
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/134305
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