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Inhibition of Akt/FOXO3a signaling by constitutively active FOXO3a suppresses growth of follicular thyroid carcinoma

Title
 Inhibition of Akt/FOXO3a signaling by constitutively active FOXO3a suppresses growth of follicular thyroid carcinoma 
Other Titles
 지속적으로 활성화된 FOXO3로 Akt/FOXO3a 신호 전달 억제시 유도되는 갑상선 난포암 성장 억제 효과 
Issue Date
2011
Publisher
 Graduate School, Yonsei University 
Description
Dept. of Medical Science/박사
Abstract
Akt-dependent FOXO3a cytoplasmic translocation is an important tumorigenic mechanism for escaping from apoptosis in cancer cells. In the present study, we examined whether non-phosphorylatable FOXO3a can inhibit cell growth of distinct follicular thyroid carcinoma(FTC) cell lines. Adenovirus carrying the FOXO3a-triple mutant (TM) sequence including point mutations at three Akt phosphorylation sites (Ad-FOXO3a-TM) was generated and transduced to the cells to mimic inhibition of Akt/FOXO3a signal. Transduction of Ad-FOXO3a-TM to FTC cells induced cell cycle arrest and apoptosis. Intratumor injection of Ad-FOXO3a-TM suppressed the growth of xenograft tumors induced in athymic mice by FTC133 cells. Consequently, our results indicate that gene therapy based on Ad-FOXO3a-TM resulting in constitutively activated FOXO3a signaling has therapeutic potential for FTC.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/134143
Appears in Collections:
2. 학위논문 > 1. College of Medicine (의과대학) > 박사
Yonsei Authors
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