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Optimal cutoff value for minimal lumen cross sectional area of coronary stents on 64-MDCT coronary angiography compared with intravascular ultrasound

Title
Optimal cutoff value for minimal lumen cross sectional area of coronary stents on 64-MDCT coronary angiography compared with intravascular ultrasound
Other Titles
다중검출컴퓨터단층촬영에서 최적의 관상 동맥 스텐트 내 재협착의 최소 단면적 기준값: 혈관내 초음파와 비교
Issue Date
2011
Publisher
Graduate School, Yonsei University
Description
Dept. of Medicine/석사
Abstract
In this study, we aimed to prospectively assess an optimal cutoff value for the minimal lumen cross sectional area (CSA) of coronary stents on 64-MDCT coronary angiography compared with intravascular ultrasound (IVUS). We performed 64-MDCT in 39 patients with 43 stents. Stenosis of more than 75% of the CSA was selected as the cutoff criterion for in-stent restenosis (ISR). The minimal lumen CSA and minimal stent CSA were measured independently on the CT images. Correlation analyses were performed between 64-MDCT and IVUS. Receiver operating characteristic (ROC) curves were calculated for the minimal lumen CSA on 64-MDCT using IVUS (significant ISR defined as minimal lumen CSA < 4mm2 on IVUS) as the gold standard. Sensitivity, specificity, positive predictive value, and negative predictive value to detect ISR using 64-MDCT were 60%, 100%, 100%, and 95%, respectively. For the assessment of minimal lumen CSA and minimal stent CSA, 64-MDCT showed a good correlation with IVUS (r = 0.73 and 0.63, p < 0.0001). However, the correlation for the area of stenosis between 64-MDCT and IVUS was weak, with a correlation coefficient of 0.29. The area under the ROC curve was 0.82 (p < 0.0001) for per-stent analysis, indicating a high degree of agreement between 64-MDCT and IVUS for significant ISR. Optimal cutoff value on 64-MDCT is 6.2mm2 using IVUS minimal CSA 4mm2 as the golden standard with sensitivity 83.33% and specificity 72%.
URI

http://ir.ymlib.yonsei.ac.kr/handle/22282913/134131
Appears in Collections:
2. 학위논문 > 1. College of Medicine (의과대학) > 석사
Yonsei Authors
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