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Efficacy of biphasic calcium phosphate and cyanoacrylate-calcium phosphate bone substitute on the circumferential defects around implants in dogs

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Dept. of Dentistry/박사
In many cases, there is no enough space of edentulous ridges for the implant installation. Circumferential gap defects around implants are easily made in case of immediate implantation. Additional surgical procedures are needed such as bone grafting and guided bone regeneration. Biphasic calcium phosphate (BCP) is one of the alloplast bone graft materials, which shows excellent biocompatibility and space maintaining properties. The newly developed cyanoacrylate-calcium phosphate bone substitute (CCP) was considered as a potential to serve as a graft material due to the plasticity and the bacteriostatic property.The aim of this study is to identify the efficacy of the animal experimental model with critical circumferential gap defects over 2mm around implants, and to determine the efficacy of BCP and CCP on the defect around implant.5 male mongrel dogs were prepared. In each side of mandible, 4 SLA surface implants with 3.8mm width and 10mm length were inserted and the circumferential gap defect with 2mm width, 5mm depth were prepared around implants in 3 implants. One gap was left empty (negative control group). The gap around the other implant was filled with BCP (BCP group). The another gap was filled with CCP (CCP group). The implants without gaps were the positive control group. After implant placement, 16 weeks of healing period was given in the one side of mandible. 8 weeks of healing period was given in the other side of mandible. The dogs were sacrificed. Histological and histometrical analysis were performed and statistically analyzed in each groups.In 8 weeks healing groups, Bone regeneration of the experimental groups with circumferential gap defects was limited. Bone height and BIC were relatively low in all the experimental groups with 8 weeks healing periods. In 16 weeks healing groups, the negative control group also showed as high BIC, bone height and bone volume as the BCP group, while the CCP group showed relatively low BIC and bone height. The BCP group showed excellent bone regeneration in both 8 weeks and 16 weeks healing period.It is suggested that BCP can be a good candidate for circumferential gap defects around implants without any barrier membrane, whereas CCP might not be appropriate for bone grafting around implants and further studies are needed for improving the cyanoacrylate bone substitutes. It is concluded that the healing around circumferential gap defects is determined by the time of healing period and bone grafting materials
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2. 학위논문 > 2. College of Dentistry (치과대학) > 박사
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