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Myeloperoxidase positive histiocytes in subacute necrotizing lymphadenitis express both CD11c and CD163

Other Titles
 아급성 괴사성 림프절염에서 Myeloperoxidase 양성 조직구의 CD11c과 CD163 면역염색 발현 
Issue Date
2012
Description
Dept. of Medicine/석사
Abstract
Immunophenotype analysis of lesional histiocytes in subacute necrotizing lymphadenitis (SNL) has revealed several unexpected findings. Histiocytes express myeloperoxidase (MPO), and immature dendritic cells occupy a significant proportion of the lesional cells in SNL. However, whether MPO-expressing lesional histiocytes of SNL also express immunophenotypic markers of immature dendritic cells has not been determined. The immunophenotypes of lesional histiocytes is analysed in paraffin-embedded tissue sections from 26 patients with SNL using a panel of dendritic cell and macrophage markers. It is performed double immunohistochemical staining to confirm coexpression of several markers. CD11c-expressing histiocytes represented a major component of lesional cells (averaging 50.1% of the lesional area), surpassing CD163-positive histiocytes (averaging 32.0% of the lesional area). Double immunohistochemical staining confirmed that a significant proportion of CD11c-expressing histiocytes also coexpressed MPO as well as CD163. CD123-positive plasmacytoid dendritic cells (averaging 3.2% of the lesional area) were minor lesional cells, and fascin-positive mature dendritic cells were not present in the lesions. Those results demonstrate that the main lesional cells in SNL are histiocytes expressing myeloid dendritic cell and macrophage markers as well as MPO, indicating phenotypic plasticity and functional versatility of histiocyte lineage cells.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/133856
Appears in Collections:
2. 학위논문 > 1. College of Medicine (의과대학) > 석사
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