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A comparison of gray and white matter density in patients with parkinson's disease dementia and dementia with lewy bodies using voxel-based morphometry

Other Titles
 복셀 기준 형태계측법을 이용한 파킨슨병 치매와 루이소체 치매환자의 회질과 백질 밀도의 비교 
Authors
 박보석 
Issue Date
2011
Description
Dept. of Medicine/석사
Abstract
Despite clinical and neuropsychological similarities between Parkinson’s disease dementia (PDD) and dementia with Lewy bodies (DLB), recent studies have demonstrated that structural and pathological changes are more severe in DLB than in PDD. We used voxel-based morphometry to compare gray and white matter densities in 20 patients with probable PDD and 18 patients with probable DLB who had similar overall severity of dementia and similar demographic characteristics. The gray matter density was significantly decreased in the left occipital, parietal, and striatal areas in patients with DLB compared to those with PDD. The white matter density was significantly decreased in bilateral occipital and left occipito-parietal areas in patients with DLB compared to those with PDD. The degree of white and gray matter atrophy was similar in patients with DLB; in contrast, there was markedly less atrophy in the white matter than in the gray matter in patients with PDD. In patients with DLB compared to those with PDD, the area of WM atrophy in the occipital areas was more extensive than that of GM atrophy. Our data demonstrate that gray and white matter atrophy is more severe in patients with DLB, and white matter atrophy relative to gray matter atrophy is less severe in patients with PDD. These data may reflect a difference in the underlying nature of PDD and DLB.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/133496
Appears in Collections:
2. 학위논문 > 1. College of Medicine (의과대학) > 석사
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