Clinical significance of serum sRAGE and esRAGE in women with physiologic pregnancy and preeclampsia

Abstract

Endogenous secretory receptor of advanced glycation end products (esRAGE) and soluble RAGE (sRAGE) have been linked to components of metabolic syndromes and pathologic pregnancy including preeclampsia, negatively. We performed this study to determine serum esRAGE and sRAGE concentrations and the esRAGE/sRAGE ratio in physiologic pregnancy and preeclampsia. Eighty-seven normal pregnant women and 28 with preeclampsia were recruited. Serum sRAGE and esRAGE levels were measured by enzyme-linked immunosorbent assay (ELISA). There were significant differences in esRAGE concentration and esRAGE/sRAGE ratio between 1st and 3rd trimester (p = .007 and p = .003). Serum esRAGE concentrations and esRAGE/sRAGE ratio in patients with preeclampsia significantly increased compared to controls (p = .012 and p = .018). Because of increased oxidative stress markers with inflammatory molecules throughout physiologic pregnancy, serum esRAGE concentration might be decreased inversely, as antioxidant defences mechanism. Elevated serum esRAGE and esRAGE/sRAGE ratio with preeclampsia might be a compensatory adaptation to neutralize oxidative stress.

[한글]

Endogenous secretory receptor of advanced glycation end products (esRAGE) 와 soluble RAGE (sRAGE) 는 대사 증후군의 한 요소이며 전자간증과도 연관되어 있다고 알려져 있다. 본 연구에서는 정상 임신과 전자간증 산모에서의 혈청 내 esRAGE 와 sRAGE 농도 및 esRAGE/sRAGE 비를 알아내고자 하였다. 87명의 정상 산모와 28명의 전자간증 산모를 대상으로 ELISA 법을 이용하여 혈청 내 sRAGE 와 esRAGE 농도를 조사하였다. 정상 산모에서 1분기와 3분기 사이에는 esRAGE 농도 및 sRAGE/sRAGE 비의 유의한 차이가 있었다. (p = .007 and p = .003). 전자간증 산모에서 혈청 내 esRAGE 농도와 esRAGE/sRAGE 비는 정상 산모와 비교하여 유의하게 증가하였다. (p = .012 and p = .018). 정상 임신에서의 증가된 oxidative stress markers with inflammatory molecules 로 인하여 혈청 내 esRAGE 농도는 antioxidant defences mechanism 으로 작용하여 역으로 감소하는 것을 추정해 볼 수 있다. 전자간증 산모에서 증가된 혈청 내 esRAGE 및 esRAGE/sRAGE 비율은 oxidative stress에 대한 compensatory adaptation 으로 해석된다.