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Quantitative comparison of the production, development and distribution of eggs of schistosoma mansoni in mice lnfected with one- and multi-paired worms

Title
Quantitative comparison of the production, development and distribution of eggs of schistosoma mansoni in mice lnfected with one- and multi-paired worms
Other Titles
『만손』住血吸蟲(schistosoma mansoni) 感染마
Issue Date
1974
Publisher
연세대학교 대학원
Description
의학과/박사
Abstract
[한글] 마우스를 兩群으로 區分하여 一群에는 各各 1 의 「만손」住血吸  cercariae를 皮下로 感染키고 他郡에는 여러  의 cercariae를 腹腔內로 注入感染시켜 成熟雌 의 産卵 및 白鼠 各 器官內에서의  卵의 分布와 發育度를 觀察한 바 다음과 같은 結論을 얻었다. 1. 感染 8∼22週의 白鼠에서 1 感染群中 發見된 15마리의 成熟雌 의 93%가 子宮內에  卵을 含有하고 있었으며 雌  한마리當  卵數 1.3個였고 여러  感染群에서는 36마리의 成熟雌 中 83%만이  卵을 含有하였으며 雌  한 마리當 平均  卵數는 0.8個였다. 2. 雌  한 마리當 1日 糞便內 排出 平均  卵數는 1 感染群에서 162個, 여러  感染群에서 267個였다. 3. 1 感染群에서 生存 卵은 肝臟에 57%, 腸管에 89%였고, 이는 여러  感染群에서 各各51%, 65%의 生存 卵보다 높은 數値였다. 4. 1 感染群에서의 排出 卵의 分布는 宿主의 肝臟에 60.7%, 小腸에 32.7%, 大腸에 6.1%였으며 0.5%는 脾臟, 肺,  臟, 賢將, 淋巴腺, 胃, 腦, 율丸 및 卵巢等 8個 器官에 分布되어 있었다. 5. 1 의 cercariae에 感染된 6마리의 마우스를 感染 82日, 89日, 302日,336日, 342日, 394日께 各各 도살하여  卵의 分布를 比較하여 본 바 糞便으로 排出된  卵은 各各 産生總 卵中 19%, 21%, 54%, 49%, 64%, 69%였으며 組織으로 排出된  卵은 81%, 79%, 46%, 51%, 36%, 31%였다. 6. 各 組織中  卵이 發見된 器官의 數는 1 感染群 15, 여러  感染群에서 18이었으며 1 感染群에서 보다 超過된 3器官은 心臟, 食道,  隔膜이었다. 7. 肝臟의 capillary sinusoid를 通해서 一般 循環系로  卵이 分布된다는 假說은 1961年 Pena de Grimaldo 및 Kershaw가 指摘한 바와 같이 肝臟系統(hepatosystem)을 떠난 他器官에서  卵이 發見된다는 觀點에서 立證되었다.
[영문] The results of infecting albino mice with presexed cercariae of S. manasoni; each with 1-pair worms percutaneously in one group, and each with multi-paired worms intraperitoneally in another group were studied in respect to production of eggs in mature females, and dispersal and developmental stages in various organs. 1) At 8~22 weeks of infection age, 93% of mature females in 1 pair worms had eggs in utero, average number per female was 1.3 eggs; and only 83% of 36 of multi-paired worms were positive, with 0.8 egg per female. 2) The average number of eggs in the feces per female per day was 162 in 1-pair worms group. The corresponding number in multipaired worms group was 267. 3) The viable eggs in liver (57%) and intestine (89%) in 1-pair worms group were higher than those in multi-paired worms group (51% and 65%). 4) Egg distributions in 1-pair worms group were; 60.7% in liver, 32.7% in small intestine, 6.1% in large intestine, and 0.5% in 8 organs (spleen, lungs, pancreas, kidneys, lymph nodes, stomach, brain and testes/ovary). 5) In 6 mice infected each with 1-pair worms, 19%, 21%, 54%, 49%, 64% and 69% of all eggs produced and passed were in the feces; and 81%, 79%, 46%, 51%, 36% and 31% were deposited in tissues in 82 89, 302, 336, 342 and 394 days after infection respectively. 6) In the tissues, the number of organs affected with eggs were 15 in 1-pair worms group, and 18 in the multi-paired worms group. The extra 3 organs complicated were the heart, esophagus and diaphragm. 7) The distpersal avenue of of eggs through the capillary sinusoid of the liver to the general circulation was postulated in view of their distribution in other organs beyond the hepatosystem (Cheever and Warren, 1963), as demonstrated by Pena de Grimaldo and Kershaw (1961).
URI

http://ir.ymlib.yonsei.ac.kr/handle/22282913/126886
Appears in Collections:
2. 학위논문 > 1. College of Medicine (의과대학) > 박사
Yonsei Authors
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