균형측 교합장애가 저작근 활성도 및 과로에 미치는 영향에 관한 연구

Abstract

[한글]

균형측 교합장애는 저작근의 활성도에 영향을 미쳐 저작계의 기능장애를 유발하는 원인으로 알려져 왔으나 이러한 이론에 대해서는 많은 논란과 이견이 있어왔다.

저자는 원광대학교 치과대학생 8명을 대상으로 하여 인위적인 균형측 교합장애를 부여한 후 저작근활성도와 과로에 관하여 연구한 결과 다음과 같은 결과를얻었다.

1. 교합장애 부여시 PRI 값은 부여 3일후 증가하였으며 2주후부터 감소되었다.

2. 3명의 피검자에게서 균형측 교합장애 부여 3 - 4일후 경미한 측두하악 장애의 증상이 관찰되었으나 1 - 2주후부터 증상의 완화를 보였다.

3. 균형측 교합장애 부여 1주후 4명의 피검자에서 교합장애 부여측으로 껌저작시 동측 측두근 전엽에서의 근활성도의 감소를 보였다.

4. 균형측 교합장애 부여3일후 3명의 피검자에서 교합장애 부여 반대측으로 껌저작시 동측 측두근 전엽의 근활성도의 증가를 보였다.

5. 균형측 교합장애는 측두근 전엽과 교근 및 악이복근의 근활성도에 현저한 영향을 주지는 않았다.

THE INFLUENCE OF BALANCING SIDE OCCLUSAL INTERFERENCE ON THE MASTICATORY MUSCLE

ACTIVITY AND CONDYLAR PATH

Tai Ho Jin, D.D.S.,M.S.D.

Department of Dental Science, The Graduate School, Yonsei University

(Directed by Prof. Ho Yong Lee, D.D.S.,M.S.D.,Ph.D.)

A new photosensitizer, CpD(Chlorophyll derivatives), previously reported as a

promising agent for tumor therapy, was studied to determine its inhibitory effects

on Gross leukemia virus(GLV), a mouse retrovirus which was isolated from the GLV

producing TGV cell line, and the cytocidal effect on the GLV infected cells in

vitro.

Following the photodynamic treatment with CpD and red light, the viral

inactivactivity of the virus itself and that in the cell-free culture supernatant

of freshly GLV-infected secondary mouse embryo cells respectively. The cytocidal

activity was measured by trpan blue exclusion test.

Significant inhibition of GLV associated RT activity resulted from CpD treatment

following the irradiation of light. The RT inhibition effect was immediate and the

infectivity of these photodynamically treated GLV to mouse embryo cells was also

significantly inhibited. However, the specific cytotoxicity for the GLV infected

cells was not recognized.

Thus it was tentatively concluded that CpD may be used as an effective

antiretroviral agent.

[영문]

A new photosensitizer, CpD(Chlorophyll derivatives), previously reported as a promising agent for tumor therapy, was studied to determine its inhibitory effects on Gross leukemia virus(GLV), a mouse retrovirus which was isolated from the GLV producing TGV cell line, and the cytocidal effect on the GLV infected cells in

vitro.

Following the photodynamic treatment with CpD and red light, the viral inactivactivity of the virus itself and that in the cell-free culture supernatant of freshly GLV-infected secondary mouse embryo cells respectively. The cytocidal activity was measured by trpan blue exclusion test.

Significant inhibition of GLV associated RT activity resulted from CpD treatment following the irradiation of light. The RT inhibition effect was immediate and the infectivity of these photodynamically treated GLV to mouse embryo cells was also

significantly inhibited. However, the specific cytotoxicity for the GLV infected cells was not recognized.

Thus it was tentatively concluded that CpD may be used as an effective antiretroviral agent.