Effect of botulinum toxin type A injection into human masseter muscle on stimulated parotid saliva flow rate

Abstract

[한글]

[영문]Botulinum toxin type A(BTX-A) injection into the masseter muscles have been used to treat masseteric hypertrophy. No serious side effects of BTX-A have been reported to date, however sometimes patients complain of xerostomia after a BTX-A injection into the masseter muscle. The aim of this study was to evaluate the effect of BTX-A into the masseter muscle for the treatment of masseteric hypertrophy on the parotid saliva flow. 32 volunteers enrolled in this study. A total of 25 units of BTX-A was injected into each side bilaterally at two points at the center of the lower 1/3 of the masseter muscle. The parotid saliva was collected from the parotid gland over a period of 10 min to determine the flow rate for 18 weeks after injection. The flow rate was calculated by dividing the amount in milliliters by the collection time in minutes. There were no significant changes in the stimulated parotid saliva flow at 4, 8, 12, 18-weeks compared with the baseline. Within this limited study, it can be concluded that BTX-A injection into the masseter muscle does not cause any significant difference in saliva production of the parotid gland.