Biphosphonate(Etidronate disodium) 투여후 치아이동에 따른 치근흡수 및 치조골 변화에 관한 연구

Abstract

[한글]

기계적인 힘을 가하여 치아를 이동시키는 교정치료시 치근흡수와 같은 불필요한 후유증이 야기될 수 있으므로 가능한 한 이를 줄이고 예방하기 위한 연구가 많이 이루어졌다.

최근에는 교정치료자체가 치근흡수의 주된 원인이라고 생각하지 않으며 치근흡수의 감수성을 증가시키는 유전적 요인 내분비이상 골대사율 변화와 같은 전구요인 중 특히 골대사변화에 영향을 주는 요인들에 관심을 갖게 되었다.

저자는 치근흡수에 감수성이 크다고 알려진 고양이를 실험동물로 하여, 골흡수를 억제시키는 약제이며 biphosphonate 화합물의 일종인 Etidronate disodium를 투여한후 60gm, 100gm의 견인력으로 치아이동시 치근흡수와 치조골에 어떤 변화가 나타나는지에 관해 광

학현미경과 주사전자현미경으로 관찰한 결과 다음과 같은 결론을 얻었다.

1. 압박부위의 치주인대 초자양 변성은 60gm의 대조군에서는 1주와 2주에, 60gm의 약제투여군에서는 1주에만 관찰되었고 낮은 빈도로 나타나는 경향을 보였다. 100gm의 대조군에서는1주 2주 4주에 걸쳐놓은 빈도로 나타난 반면 100gm의 약제투여군에서는 1주 2주에

낮은 빈도로 나타났다.

2. 백아질 흡수와 치조골 흡수는 100gm의 대조군에서는 2주에 급격히 증가한 반면 100gm의 약제투여군에서는 거의 나타나지 앉는 경향을 보였다. 60gm의 약제투여군에서는 치조골과 백아질의 흡수나 형성소견이 전 실험기간을 통해 나타나지 않았다.

3. 백아질 형성과 치조골 형성은 100gm의 대조군에서는 1주에서부터 나타난 반면 100gm의 약제투여군에서는 백아질 형성은 2주부터, 치조골 형성은 4주에 나타났으며 60gm의 대조군에서 백아질 형성소견은 전 실험기간동안 관찰되지 않았다.

4. 주사전자현미경 관찰결과 대조군에서는 60gm군보다 100gm군에서 2주에 치근흡수가 많이 나타났으며 약제투여군에서는 가한 힘에 관계없이 치근흡수 양상이 나타나지 않았다.

A STUDY OF ROOT RESORPTION AND ALVEOLAR BONE CHANGES DURING TOOTH MOVEMENT AFTER

TREATMENT WITH ETIDRONATE DISODIUM

Chung-Ju Hwang

Department of Dental Science, The Graduate School, Yonsei University

(Directed by Prof. Byung-Hwa Sohn, D.D.S., M.S.D., Ph.D.)

Many studies has been conducted concerning prevention of unnecessary

complications such as root resorption during orthodontic tooth movement under

various mechanical forces.

Nowadays, the cause of the root resorption is not thought to be confuted only to

mechanical forces. But the factor that affects bone metabolism are thought to be

major one of the predisposing factors.

The light microscope and scanning electron microscope were used to the effects of

60gm, and 100gm of tipping farce on root resorption of cats, which were treated

with Etidronate disodium. The results were as follows:

1. In the 60gm control group, hyalinization on the compression site of

periodontal ligament appeared after first week and second week. In the 60gm

experimental group, it appeared after first week with low frequency, In the 100gm

control group it appeared with high frequency by firsts and second week while in

100gm experimental group, it appeared with low frequency.

2. In the 100gm control group, resorption of the cementum and the alveolar bone

rapidly increased after second week. In the 60gm experimental group, resorption or

formation of alveolar bone and cementum didn't appear all through the experimental

period.

3. In the 100gm control group, formation of cementum and alveolar bone appeared

after first week while in the 100gm experimental group, formation of cementum and

alveolar bone appeared after second week and fourth week respectively. In the 60gm

control group, formation of the cementum didn't appear all through the experimental

period.

4. In the control group, the root resorption of 100gm group was higher trim that

of 60gm group after second week while in experimental group, root resorption didn't

appear regardless of the forces.

[영문]

Many studies has been conducted concerning prevention of unnecessary complications such as root resorption during orthodontic tooth movement under various mechanical forces.

Nowadays, the cause of the root resorption is not thought to be confuted only to mechanical forces. But the factor that affects bone metabolism are thought to be major one of the predisposing factors.

The light microscope and scanning electron microscope were used to the effects of 60gm, and 100gm of tipping farce on root resorption of cats, which were treated with Etidronate disodium. The results were as follows:

1. In the 60gm control group, hyalinization on the compression site of periodontal ligament appeared after first week and second week. In the 60gm experimental group, it appeared after first week with low frequency, In the 100gm control group it appeared with high frequency by firsts and second week while in 100gm experimental group, it appeared with low frequency.

2. In the 100gm control group, resorption of the cementum and the alveolar bone rapidly increased after second week. In the 60gm experimental group, resorption or formation of alveolar bone and cementum didn't appear all through the experimental period.

3. In the 100gm control group, formation of cementum and alveolar bone appeared after first week while in the 100gm experimental group, formation of cementum and alveolar bone appeared after second week and fourth week respectively. In the 60gm control group, formation of the cementum didn't appear all through the experimental period.

4. In the control group, the root resorption of 100gm group was higher trim that of 60gm group after second week while in experimental group, root resorption didn't appear regardless of the forces.