성견에서 발치 직후 Titanium plasma sprayed IMZ 임프란트 이식시 조직 유도 재생술에 따른 골 재생력에 관한 연구

Abstract

[한글]

성견의 하악 발치와내에 임프란트 이식시 인위적인 골 결손부위에 다공성 hydroxyapatite 입자(Interpore 200**(R))와 조직유도 재생막(Gore-Texn**TM augmentation membrane) 사용에 따른 신생 골조직 형성의양 및 형태를 관찰하기 위하여 협측에는 폭 3.3mm, 깊이

3.Omm의 인위적인 골 결손부위를 만들고 IMZ 임프란트 이식 후 봉합한 것을 대조군, 조직유도 재생막을 피개한 후 봉합한 것을 실험 1군, 결손부위에 HA를 축조하고 조직유도 재생막으로 피개한 후 봉합한 것을 실험 2군으로 하여 임프란트 이식 16주 후 동물을 회생

시켜 임프란트 주변과 골 결손부위의 골형성 양 및 형태를 광학현미경적, 형광현미정적으로 관찰하여 다음과 같은 결론을 얻었다.

1. 임프란트와 골과의 계면에서는 세군 모두 연조직의 하방 이주없이 골유착이 관찰되었다.

2. 골 결손부의 신생골 생성정도는 임프란트만 이식한 대조군에 비해 실험군은 결손부위의 폭과 높이를 유지하며 골형성이 진행되었으며, 특히 실험 1군의 골형성이 현저하였다.

3. 형광현미경적 소견상 실험 1군은 골 결손부위에 재형성된 골부위에서도 피질골로의 골개형이 관찰되었으나, 실험 2군은 골성장 부위에서 불규칙, 블연속성의 형광대가 관찰되었을 뿐, 골 개형 소견은 미약하였다.

이상의 결과를 토대로 발치 후 즉시 임프란트를 이식하고 조직유도 재생막을 피개하는 것이 연조직의 개입없이 골형성을 촉진시킨다는 것을 확인할 수 있었으나 다공성 HA축조에 따른 비계의 역할과 골조직으로의 완전한 치유는 즘 더 장기적이고 다각적인 연구가

필요하리라 사료되는 바이다.

A STUDY OF GUIDED TISSUE REGENERATION FOR IMMEDIATE IMPLANTATI0N WITH/WITHOUT HA

AUGMENTATI0N : A STUDY IN DOGS

Hie Seong Hwang, D.D.S., M.S.D.

Department of Dental science, Graduate School, Yonsei University

(Directed by Moon Kyu Chung, D.D.S., M.S.D. Ph.D.)

The purpose of this investigation was to evaluate the effect of the porous

hydroxyapatite particles (Interpore 200**(R)) and guided tissue regeneration

membrane (Gore-Tex**TM augmentation material) on amount and shape of generating new

bone adjacent to implant.

Implants were placed immediately after extraction in the bilateral 3rd, 4th

premolars of the mandible of the adult dogs.

In all experimental groups, artificial bony defects were formed at the buccal

cortex area,3.3mm in width and 3.0mm in depth.

In the control group : sutured without HA particles & membranes after placing

implants, the experimental group 1 : membrane was place over the artificial bony

defect, the experimental group 2 : bony defect was filled with HA particles and

covered with membrane.

The examination of bone-implant interfaces using light microscope and fluorescent

microscope concluded as follows

1. In all three experimental groups, osseointegration was observed without

epitherial migration.

2. In the healing degree of bony defect area, the experimental group 1, 2 showed

more prominent healing than control group, and the experimental group 1 showed the

most excellent bone formation.

3. In fluorescent microscopic finding bone remodeling was observed in regenerated

bone tissue at defect area of experimental group 1, but in experimental group 2,

irregular, discontinuous linear fluorescence was observed at the lower portion of

defect area and si후 of bone remodeling was weak.

[영문]

The purpose of this investigation was to evaluate the effect of the porous hydroxyapatite particles (Interpore 200**(R)) and guided tissue regeneration membrane (Gore-Tex**TM augmentation material) on amount and shape of generating new bone adjacent to implant.

Implants were placed immediately after extraction in the bilateral 3rd, 4th premolars of the mandible of the adult dogs.

In all experimental groups, artificial bony defects were formed at the buccal cortex area,3.3mm in width and 3.0mm in depth.

In the control group : sutured without HA particles & membranes after placing implants, the experimental group 1 : membrane was place over the artificial bony defect, the experimental group 2 : bony defect was filled with HA particles and covered with membrane.

The examination of bone-implant interfaces using light microscope and fluorescent microscope concluded as follows

1. In all three experimental groups, osseointegration was observed without epitherial migration.

2. In the healing degree of bony defect area, the experimental group 1, 2 showed more prominent healing than control group, and the experimental group 1 showed the most excellent bone formation.

3. In fluorescent microscopic finding bone remodeling was observed in regenerated bone tissue at defect area of experimental group 1, but in experimental group 2, irregular, discontinuous linear fluorescence was observed at the lower portion of defect area and si후 of bone remodeling was weak.