4. 2주째에서 porous tricalcium phosphate군에는 염증소견이 없었고, dense tricalcium phosphate군에는 탐식세포와 만성염증세포의 침윤이 보였으며, 두군 모두에서 4주째에는 탐식세포의 침윤과 골흡수 소견이, 8주째에는 탐식세포 및 염증세포와 조골세포 및 파골세포의 침윤이 관찰되었다.
A STUDY OF TISSUE REACTIONS TO CALCIUM PHOSPHATE CERAMICS ON SUBPERIOSTEAL IMPLANTS
IN DOGS
Soon Ho Hong, D.D.S.
Department of Dental Science, The Graduate School, Yonsei University
(Directed by Prof. Ho Yong Lee, D.D.S., M.S.D., Ph.D.)
The purpose of this study was to observe the tissue reactions to four
experimental groups of calcium phoshpate ceramics, which are porous hydroxyapatite,
dense hydroxyapatite, porous tricalcium phosphate and dense tricalcium phosphate
implants, and to the control group of surgical grade Vitallium(Howmedica Inc., New
York, N.Y.) after 3 days, 1 week, 2 weeks, 4 weeks and 8 weeks from subperiosteal
implantation on maxillary buccal mucosa of 5 dogs.
The results were obtained as follows :
1. In all experimental and control groups, marked infiltration of acute and
chronic inflammatory cells were observed after 3 days, and resorption of alveolar
bone, covering of connective tissue with marked decrease in inflammatory reaction
were observed after 1 week.
2. In control group, the following were observed covering of the thick fibrous
tissue wall and infiltration of acute and chronic inflammatory cells as well as
resorption of alveolar bone after 2 weeks, and covering of fibrous tissue wall,
infiltration of osteoblasts and resorption of alveolar bone after 4 weeks, but
after 8 weeks only the covering of the fibrous tissue wall.
3. After 2 and 4 weeks, covering of thin fibrous tissue wall without any
inflammatory reaction were observed from porous hydroxyapatite and dense
hydroxyapatite groups, with additional infiltration of macrophage and resorption of
alveolar bone from dense hydroxyapatite groups after 4 weeks, and after 8 weeks,
infiltration of macrophages and inflammatory cells as well as osteoblasts and
osteoclasts were observed in both groups.
4. After 2 weeks no inflammatory reaction from porous tricalcium phosphate group,
and infiltration of macrophage and chronic inflammatory cells from dense tricalcium
phosphate group, but after 4 weeks resorption of alveolar bone with infiltration of
macrophages, and after 8 weeks, infiltration of macrophages and inflammatory cells
as well as osteoblasts and osteoclasts were observed in both groups.
[영문]
The purpose of this study was to observe the tissue reactions to four experimental groups of calcium phoshpate ceramics, which are porous hydroxyapatite, dense hydroxyapatite, porous tricalcium phosphate and dense tricalcium phosphate implants, and to the control group of surgical grade Vitallium(Howmedica Inc., New
York, N.Y.) after 3 days, 1 week, 2 weeks, 4 weeks and 8 weeks from subperiosteal implantation on maxillary buccal mucosa of 5 dogs.
The results were obtained as follows :
1. In all experimental and control groups, marked infiltration of acute and chronic inflammatory cells were observed after 3 days, and resorption of alveolar bone, covering of connective tissue with marked decrease in inflammatory reaction were observed after 1 week.
2. In control group, the following were observed covering of the thick fibrous tissue wall and infiltration of acute and chronic inflammatory cells as well as resorption of alveolar bone after 2 weeks, and covering of fibrous tissue wall, infiltration of osteoblasts and resorption of alveolar bone after 4 weeks, but
after 8 weeks only the covering of the fibrous tissue wall.
3. After 2 and 4 weeks, covering of thin fibrous tissue wall without any inflammatory reaction were observed from porous hydroxyapatite and dense hydroxyapatite groups, with additional infiltration of macrophage and resorption of alveolar bone from dense hydroxyapatite groups after 4 weeks, and after 8 weeks,
infiltration of macrophages and inflammatory cells as well as osteoblasts and osteoclasts were observed in both groups.
4. After 2 weeks no inflammatory reaction from porous tricalcium phosphate group, and infiltration of macrophage and chronic inflammatory cells from dense tricalcium phosphate group, but after 4 weeks resorption of alveolar bone with infiltration of macrophages, and after 8 weeks, infiltration of macrophages and inflammatory cells as well as osteoblasts and osteoclasts were observed in both groups.