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식이 및 타액분비가 백서치아우식 발생에 미치는 영향에 관한 실험적 연구

Other Titles
 Experimental studies on the effect of cariogenic diet and salivation on the dental caries in albino rats 
Issue Date
1980
Description
치의학과/박사
Abstract
[한글] 치아우식증의 발생원인과 기전 및 예방관리의 원리를 구명하려는 많은 노력의 결과 여러 가지 복잡한 인자들이 관여함이 밝혀졌으며 그 중에서도 식이의 성분 및 세균의 역할이 중요함이 인지되었다. 그러나 아직껏 밝혀지지 않은 부분이 많아 실험동물에 의한 치아우식 발생에 관한 연구가 계속 보고되어 오고 있다. 치아우식 발생에 관한 연구를 함에 있어 실험동물로서는 백서가 가장 적합함이 알려진 바 있어 저자는 연세대학교 의과대학 동물실에서 사육하고 있는 생후 21∼25일의 체중 40gm내외의 자성 백서 60두에 우식성식이와 타액분비에 영향을 미치는 약제를 투여하며 90일간 사육한 후 우식 발생의 양상을 검토하여 다음과 같은 결론을 얻었다. 제1군 : balanced diet+water 제2군 : balanced diet+pilocarpine water 제3군 : balanced dist+atropine water 제4군 : cariogenic diet+water 제5군 : cariogenic diet+pilocarpine water 제6군 : cariogcnic diet+atropine water 1. cariogenic diet 군들이 balanced diet 군들에 비하여 성장이 극히 저조하였으며 타액분비가 성장에 미치는 영향은 별로 관찰되지 않았다. 2. 치아우식발생이 6군> 4군> 5군> 3군> 1군> 2군의 순서로서 식이가 우식발생에 미치는 영향이 크며 타액분비도 치아우식발생과 밀접한 관계가 있음이 확인되었다. 3. 상하악간의 우식발생은 하악이 상악보다 다소 높은 것으로 나타났다. 4. 백서우식관찰연구에 위상차 현미경 관찰에 의한 major sulcal scoring이 권장할만하다. EXPERIMENTAL STUDIES ON THE EFFECT OF CARI0GENIC DIET AND SALIVATION ON THE DENTAL CARIES IN ALBINO RATS Sung-Hoon, Han. D.D.S.,M.S.D. Dept. of Dental Science, Graduate School, Yonsei Univ. (Directed by prof. Chong-you, Kim.D.D.S., M.S.D., Ph.D.) The author had divided the sixty female weaning albino rats from Yonsei University-Animal House into following 6 groups and the rats were fed for 90 days. Group 1 : balanced diet + water Group 2 : balanced diet + pilocarpine water Group 3 : balanced diet + atropine water Group 4 : cariogenic diet + water Group 5 : cariogenic diet + pilocarpine water Group 6 : cariogenic diet + atropine water At this time, the animals were sacrified and the induced dental caries had been observed according to the caries rate, the carious teeth index and caries score by Keyes'method. The results were as followings; 1. The average gain of body weight in cariogenic diet groups was much less than that of in balanced diet groups. 2. The dental caries susceptibility order was as follows, group 6> group 4> group 5> group 3>, group 1> group 2. This shows influence to dental caries susceptibility of diet was very significant and the influence of salivary flow was significant too. 3. The caries scores of lower molars were somewhat higher than the scores of upper molars. 4. The method by phase difference microscope were recommendable for major sulcal scoring for experimental dental caries study of rats.
[영문] The author had divided the sixty female weaning albino rats from Yonsei University-Animal House into following 6 groups and the rats were fed for 90 days. Group 1 : balanced diet + water Group 2 : balanced diet + pilocarpine water Group 3 : balanced diet + atropine water Group 4 : cariogenic diet + water Group 5 : cariogenic diet + pilocarpine water Group 6 : cariogenic diet + atropine water At this time, the animals were sacrified and the induced dental caries had been observed according to the caries rate, the carious teeth index and caries score by Keyes'method. The results were as followings; 1. The average gain of body weight in cariogenic diet groups was much less than that of in balanced diet groups. 2. The dental caries susceptibility order was as follows, group 6> group 4> group 5> group 3>, group 1> group 2. This shows influence to dental caries susceptibility of diet was very significant and the influence of salivary flow was significant too. 3. The caries scores of lower molars were somewhat higher than the scores of upper molars. 4. The method by phase difference microscope were recommendable for major sulcal scoring for experimental dental caries study of rats.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/117316
Appears in Collections:
2. 학위논문 > 2. College of Dentistry (치과대학) > 박사
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