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백반증환자에서 표피 Langerhans 세포수의 변화에 관한 연구

Title
백반증환자에서 표피 Langerhans 세포수의 변화에 관한 연구
Other Titles
Quantitative study of epidermal LC in vitiligo
Issue Date
1987
Publisher
연세대학교 대학원
Description
의학과/석사
Abstract
[한글] 백반증의 기전과 Langerhans세포(LC)의 숫적변화에 대해서 여러가지 많은 보고들이 있으나 아직 정설이 없는 상태이다. 더우기 백반증병변 및 바로 인접한 정상피부에서의 표피 LC수의 변화에 관한 문헌보고는 찾아 볼 수 없는 실정이다. 이에 저자들은 전신성 백반증환자 18명을 대상으로 백반증 병변피부와 인접정상피부에서 표피LC수의 차이를 조사하기 위하여 본 연구를 착수하였다. 본 연구에서 Adenosine triphosphatase ( ATPase )염색법으로 LC를 염색하고, eye piece micrometer로 표피LC밀도를 mm**2당 세포수로 계산하여 다음과 같은 결과를 얻었다. 1. 병변표피에서의 ATPase양성 LC수는 신체부위별로 차이가 많아서 1mm**2당 세포수는 581±21개 내지 1647±110개였으며, 평균 세포수는 1006.7±337개였다. 2. 인접정상표피에서의 ATpase양성 LC수 역시 신체부위별로 차이가 많아서 1mm**2당 세포수는 668± 65개였으며, 1241±31개 였으며, 평균세포수는 944±258개였다. 3. 백반증환자의 인접정상표피의 ATPase 양성 LC수는 통계학적으로 유의한 차이가 없었다. 이상의 결과로 보아 ATPase 양성 LG수의 변화와 백반증의 병인론과는 유의한 관계가 없는 것으로 사료된다. Quantitative Study Of Epidermal LC in Vitiligo Seung Kyung Hann Department of Medical Science, The Graduate School, Yonsei University (Directed by Professor Yoon-Kee Park, M.D.) There has not been an established theory regarding mechanism of vitiligo, although many articles about the relationship between mechanism of vitiligo and numeric change of epidermal Langerhans cell (LC) have been reported. In addition the reports about numeric change of LC between vitiliginous skin (VS) and adjacent normal apperring skin (ANAS) are impossible to find. Epidermal LC densities in VS and ANAS were studied in 18 patients withigeneralized vitiligo. Adenosine triphosphatase (ATPase) stain was used to characterize LC. Epidermal LC densities were calculated by means of an eye piece micrometer and expressed per mm**2. The results were as follows: 1. There was significant body site variation of LC densities on VS and the range of densities of LC per mm**2 were from 581±21 to 1647±110 and the mean density of LC per mm**2 was 1006.7±337. 2. There was also significant body site variation of the densities on ANAS and the range of densities of LC per mm**2 were from 668±165 to 1241±31 and the mean density of LC per mm**2 was 944±258. 3. The LC densities of VS was similar to that of ANAS (p: not significant). In conclusion quantitative change of epidermal LC in vitiligo doesn't seem to have significant relation with pathogenesis of vitiligo.
[영문] There has not been an established theory regarding mechanism of vitiligo, although many articles about the relationship between mechanism of vitiligo and numeric change of epidermal Langerhans cell (LC) have been reported. In addition the reports about numeric change of LC between vitiliginous skin (VS) and adjacent normal apperring skin (ANAS) are impossible to find. Epidermal LC densities in VS and ANAS were studied in 18 patients withigeneralized vitiligo. Adenosine triphosphatase (ATPase) stain was used to characterize LC. Epidermal LC densities were calculated by means of an eye piece micrometer and expressed per mm**2. The results were as follows: 1. There was significant body site variation of LC densities on VS and the range of densities of LC per mm**2 were from 581±21 to 1647±110 and the mean density of LC per mm**2 was 1006.7±337. 2. There was also significant body site variation of the densities on ANAS and the range of densities of LC per mm**2 were from 668±165 to 1241±31 and the mean density of LC per mm**2 was 944±258. 3. The LC densities of VS was similar to that of ANAS (p: not significant). In conclusion quantitative change of epidermal LC in vitiligo doesn't seem to have significant relation with pathogenesis of vitiligo.
URI

http://ir.ymlib.yonsei.ac.kr/handle/22282913/117314
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2. 학위논문 > 1. College of Medicine (의과대학) > 석사
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