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한 사업장에서의 B형 간염 백신 접종후 생성된 항체 발현에 관한 연구

Other Titles
 (A) study of the seroconversion rates of anti HBs and the duration of anti HBs persistence after hepatitis B vaccination 
Issue Date
1989
Description
보건학과/석사
Abstract
[한글] 간염 백신접종후 항체생성여부와 항체지속기간을 파악하고 항체지속 기간에 영향을 미치는 변수를 분석하고자 한 사업장에서의 건강진단기록을 기초로 연구하여 카이자승 검정과 생존분석법으로 통계처리하여 다음과 같은 연구결과를 얻었다. 1. B형 간염 백신접종후 간염표면항체(Anti HBs) 양성률은 67.2% 였다. 2. 항체양성률에 영향을 주는 변수는 성, 연령, 흡연습관, 백신종류, 혈액형이었다. 여자의 항체양성률(75.5%)이 남자(62.1%)의 항체양성률보다 유의하게 높았으며, 남자의 항체양성률은 연령별로 유의한 차이가 있어 20대와 40대에서 높게 나타났다. 흡연습관, 백 신종류와 혈액형별로 본 항체양성률에 차이가 있었으나, 각기 성과 연령을 교정한 후에는 흡연습관 및 혈액형별 항체양성률에 차이가 없었다. 3. 3회의 백신접종완료자 661명중 B형 간염표면항체에 양성을 보인 사람은 444명(67.2%)이었고, 이들에게서의 5년 항체지속률은 57.3%이었다. 4. 항체지속기간에 영향을 미치는 변수는 Quetelet index와 간질환 과거력이었다. Quetelet index가 증가할수록 항체지속기간이 짧았으며 간질환과거력이 없는 그룹의 항체지속기간이 더 길었다. 항체지속기간은 표준체중에 속하면서 간질환과거력이 없는 집단에서 가장 길게 나타났다. A Study of the Seroconversion rates of Anti HBs and the Duration of Anti HBs Persistence after Hepatitis B Vaccination Bok Soon Han Graduate School of Health Science and Management Yonsei University (Directed by Professor Il Soon Kim M.D., Ph.D.) When the patients were contracted with acute type B hepatitis, most of them recovered completely. But approximately 15-20% of them may have chronic hepatitis, liver cirrhosis or hepatoma. For the prevention of serious type B hepatitis, many different products of vaccine were developed And there were many researches on the effectiveness, security and immunity of these products. The purpose of this study is to assess the seroconversion rates of Anti HBs with PHA method and the duration of Anti HBs persistence after hepatitis B vaccination. The factors relevant to the rates and duration were analyzed using x**2 test and survival analysis based on the data from self - written questionnaires, blood test and chart rieviews from Oct. 1988 to May. 1989. The results were as follow : 1. The seroconversion rate of Anti HBs was 67.2%. 2. The statistically significant variables influencing seroconversion rates of Anti HBs after hepatitis B vaccination were sex, age, type of vaccines, blood types, smoking. 3. The seroconversion rates for male and female were 62.1% and 75.5%, respectively. These rates were statistically significant (p<0.05). For male, the age specific rates for 19-29, 30-39, 40-49, 50 over were 73.6%, 57.3%, 74.6%, 52.0%, respectively. These rates were also statistically significant (p<0.05). 4. Of the 661 cases of completely hepatitis B vaccinated persons, 444 cases(67.2%) were responders with vaccination, Their 5 year survival rate of Anti HBs was 57.3%. 5. The statistically significant variables influencing survival time of Anti HBs were Quetelet index and past history of liver diseases. The lower the Quetelet index, the more mean survival time of Anti HBs. The mean survival time of Anti HBs for the persons with no history of liver disease was longer than that of the persons with history of fiver disease. 6. The mean survival time of Anti HBs of Quetelet index group for the average weight, overweight and obesity were 55.82 months, 51.37 months and 35.57 months, respectively. 7. The mean survival time of Anti HBs for the persons with no history of liver disease, the persons with history of liver disease were 57.31 months and 40.01 months, respectively.
[영문] When the patients were contracted with acute type B hepatitis, most of them recovered completely. But approximately 15-20% of them may have chronic hepatitis, liver cirrhosis or hepatoma. For the prevention of serious type B hepatitis, many different products of vaccine were developed And there were many researches on the effectiveness, security and immunity of these products. The purpose of this study is to assess the seroconversion rates of Anti HBs with PHA method and the duration of Anti HBs persistence after hepatitis B vaccination. The factors relevant to the rates and duration were analyzed using x**2 test and survival analysis based on the data from self - written questionnaires, blood test and chart rieviews from Oct. 1988 to May. 1989. The results were as follow : 1. The seroconversion rate of Anti HBs was 67.2%. 2. The statistically significant variables influencing seroconversion rates of Anti HBs after hepatitis B vaccination were sex, age, type of vaccines, blood types, smoking. 3. The seroconversion rates for male and female were 62.1% and 75.5%, respectively. These rates were statistically significant (p<0.05). For male, the age specific rates for 19-29, 30-39, 40-49, 50 over were 73.6%, 57.3%, 74.6%, 52.0%, respectively. These rates were also statistically significant (p<0.05). 4. Of the 661 cases of completely hepatitis B vaccinated persons, 444 cases(67.2%) were responders with vaccination, Their 5 year survival rate of Anti HBs was 57.3%. 5. The statistically significant variables influencing survival time of Anti HBs were Quetelet index and past history of liver diseases. The lower the Quetelet index, the more mean survival time of Anti HBs. The mean survival time of Anti HBs for the persons with no history of liver disease was longer than that of the persons with history of fiver disease. 6. The mean survival time of Anti HBs of Quetelet index group for the average weight, overweight and obesity were 55.82 months, 51.37 months and 35.57 months, respectively. 7. The mean survival time of Anti HBs for the persons with no history of liver disease, the persons with history of liver disease were 57.31 months and 40.01 months, respectively.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/117306
Appears in Collections:
2. 학위논문 > 4. Graduate School of Public Health (보건대학원) > 석사
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