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사람다형핵 백혈구에 의한 Candida albicans의 탐식작용에 대한 전자현미경적 연구

Title
사람다형핵 백혈구에 의한 Candida albicans의 탐식작용에 대한 전자현미경적 연구
Other Titles
Studies on the ultrastructural changes of phagocytosis of candida albicans by human polymorphonuclear leukocytes
Issue Date
1985
Publisher
연세대학교 대학원
Description
치의학과/석사
Abstract
[한글] Candida albicans에 대한 사람의 다형핵백혈구의 탐식능과 세포의 변화양상을 전자현미경을 통하여 관찰하였던 바 다음과 같은 결론을 얻었다. 1. 다형핵백혈구의 Candida albicans에 대한 탐식능은 다형핵백혈구 부유액과 Candida albicans의 부유액을 혼합처리한 후 30분 경과군은 80.73%, 60분 경과군은 87.25%, 그리고 240분 경과군은 89.25%의 탐식능을 나타내었으며 10분 경과군에서는 탐식현상을 관찰할 수 없었다. 2. 미세구조학적 변화는 탐식 30분후의 다형핵백혈구는 정상세포와 별차 없었으나 단지 phagocytic vacuole내에 Canada albicans가 존재하고 있었다. 3. 시간경과에 따른 Candida albicans의 미세구조학적 변화는 탐식 4시간후 세포벽의 일부소실과 세포벽 주위에 백혈구에 존재하는 azurophilic granule과 전자밀도가 같은 물질들이 많이 침착되어 있는 반면 백혈구 내에는 azurophilic granule이 소멸되어 없어진 것을 관찰할 수 있었다. 이 현상은 Candida cell의 세포내 소화(intracellular digestion)를 위한 작용의 하나로 사료된다. STUDIES ON THE ULTRASTRUCTURAL CHANGES OF PHAGOCYTOSIS OF CANDIDA ALBICANS BY HUMAN POLYMORPHONUCLEAR LEUKOCYTES Jung Won Choi, D.D.S. Dept. of Dental Science, Graduate School, Yonsei University (Directed by Professor Eui Wung Lee, D.D.S., M.S.D., Ph.D.) This study was undertaken to observe the phagocytosis of the candida albicans by human polymorphonuclear leukocytes and the ultrastructural changes of candida albicans in the poly-morphonuclear leukocytes. The obtained results were as follows: 1. Normal human polymorphonuclear leukocytes ingested 80.73% of candida albicans after 30minutes, 87.25% after 60 minutes and 89.25% after 240 minutes. No remarkable increase was observed after 60 minutes and no phagocytosis after 10 minutes incubation. 2. Electron microscopic findings revealed no specific changes with normal polymorphonuclear leukocyte cell after 30 minutes but candida albicans were in the loose phagocytic vacuoles. 3. Ingested candida albicans showed partial disruption of if cell wall in 240 minutes and large amount of azurophilic granule like materials were deposited surrounding the cell wall, whereas loss of them was observed in polymorphonuclear leukocytes. This evidence is considered as an action for an intracellular digestion .
[영문] This study was undertaken to observe the phagocytosis of the candida albicans by human polymorphonuclear leukocytes and the ultrastructural changes of candida albicans in the poly-morphonuclear leukocytes. The obtained results were as follows: 1. Normal human polymorphonuclear leukocytes ingested 80.73% of candida albicans after 30minutes, 87.25% after 60 minutes and 89.25% after 240 minutes. No remarkable increase was observed after 60 minutes and no phagocytosis after 10 minutes incubation. 2. Electron microscopic findings revealed no specific changes with normal polymorphonuclear leukocyte cell after 30 minutes but candida albicans were in the loose phagocytic vacuoles. 3. Ingested candida albicans showed partial disruption of if cell wall in 240 minutes and large amount of azurophilic granule like materials were deposited surrounding the cell wall, whereas loss of them was observed in polymorphonuclear leukocytes. This evidence is considered as an action for an intracellular digestion.
URI

http://ir.ymlib.yonsei.ac.kr/handle/22282913/117241
Appears in Collections:
2. 학위논문 > 2. College of Dentistry (치과대학) > 석사
Yonsei Authors
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