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베체트 병에서 빈혈에 관한 연구

Issue Date
1992
Description
의학과/석사
Abstract
[한글] 베체트 병은 한국, 일본, 중국 등 동남아시아지역과 중동, 지중해 연안을 연결하는 지역에 호발하며 동남아시아 지역에서는 여자에서 호발하고, 지중해 연안 및 유럽 지역에서는 남자에서 호발하역학적 특성을 가지는 질환이다. 최근의 연구들은 이러한 지역간의 남녀 비의 차이가 식이상태나 무기원소대사의 차이와 연관이 있음을 시사하고 있다. 연구자는 빈혈과 베체트 병과의 관개를 보기 위해 연세대학교 의과대학 세브란스병원 베체트 병 특수진료실에 내원한 베체트 병 환자 520명의 혈색소치, 적혈구용적, 혈중 아연치 와 혈중 구리치를 분류아형에 따라 분석하여 다음과 같은 결과를 얻었다. 1. 베체트 병 환자에서 빈혈이 28%(520명 중 143명)로 정상인의 11%(204명 중 22명)보다 높은 빈도로 나타났다. 2. 빈혈의 유무는 남자에서 16%(229명 중 37명), 여자에서 36%(291명 중 106명)로 성별에 따라 뚜렷한 차이가 있었다. 3. 빈혈의 유무나 혈색소치는 연령이나 유병기간과는 무관하였다. 4. Shimizu의 분류아령별 빈혈의 빈도는 완전형 47%(85명중47명), 불완전형 29%(222명중 65명), 용의형 19%(136명중26명), 가능형 16%(77명중 12명)의 순으로 나타났다. 5. Lehner의 분류아형별 빈혈의 빈도는 관절형 67%(81명 중 54명), 신경형57%(7명 중 4명), 안형 34%(119명 중 41명), 점막피부형 14%(313명 중 설명)의 순으로 나타났다. 6. 혈중 아연치는 빈혈이 있는 경우 평균 93.5±25.5μg/dl, 빈혈이 없는 경우 평균 101.3±26.4μg/dl로 빈혈 유무에 따른 통계학적 차이(p<0.05)가있었고 혈색소치와도 회귀계수 3.15로 유의한 관계(p<0.01)에 있었다. 7. 혈중 구리치는 빈혈이 있는 경우 평균 151.2±43.0μg/dl, 빈혈이 없는 경우 평균 138.1±36.5μg/dl로 빈혈유무에 따른 통계학적 차이(p<0.05)가있었고 혈색소치와도 회귀계수 -6.37로 유의한 관계(p<0.01)에 있었다. 본 연구는 무시하기 쉬운 불현성 빈혈과 베체트 병의 병인에 관한 관계를 밝히며, 여자 환자에서 빈혈의 빈도가 높음을 밝힘으로서 호발 국가간의 남녀 발생 빈도의 차이를 설명함에 간접적 자료가 될 것으로 판단된다. Study on Anemia in Patients with Behcet's Disease Yong Seop Choi Department of Medical Science, The Graduate School, Yonsei University (Directed by Assistant Professor Dongsik Bang) Behcet's disease has been more commonly seen in the Far East(Korea, Japan, China), the Middle East and the Mediterranean area. In the Far East, Behcet's disease occurs more commonly in women than men, However, male predominance is noted in the Mediterranean area, Europe and America. Recently, the study on dietary habits in patients with Behcet's disease in Korea suggest that dietary habits and mineral metabolism are related to geographic differences of male to female ratios. As we know, iron is one of the important factors in cell mediated immunity. The present study was performed to determine the hemoglobin levels, which is associated with iron levels, in our patients with Behcet's disease in relation to clinical types, serum zinc and copper. The followings are the results summarized : 1. Higher frequency of anemia in patients with Behcet's disease(28%) than normal persons(11%) was found. 2. Higher frequency of anemia in female(36%) than male patients(16%) with Behcet's disease was found. 3. There was no statistical significance between frequency of anemia or hemoglobin level and age of patients or duration of Behcet's disease, 4. In adherence to Shimizu's classification, the percentage of anemia found is as follows ; 47%(40 in 85) in the complete type, 29%(65 in 222) in the incomplete type, 19%(26 in 136) in the Suspected type and 16%(12 in 77) in the possible type. 5. In adherence to Lehner's classification, the percentage of anemia found is as fellows ; 67%(54 in 81) in the arthritc type, 57%(4 in 7) in the neurologic type, 34%(41 in 119) in the ocular type and 14%(44 in 313) in the mucocutaneous type. 6. Statistically significant differences in serum zinc levels between the group of patients with anemia(mean serum zinc = 93.5±25.5μg/dl) and without anemia(mean serum zinc = 101.3±26.4μg/dl) were noted. There was a positive correlation between serum zinc levels and hemoglobin levels(regression coefficient = 3.15). 7. Statistically significant differences in serum copper levels between the group of patients with anemia (mean serum copper = 151.2±43.0μg/d1) and without anemia(mean serum copper = 138.1±36.5μg/dl) were noted. There was a negative correlation between serum copper levels and hemoglobin levels (regression coefficient = -6.37). In conclusion, the results of this study suggest that anemia is one of the possible causes of geographic differences of male to female ratios because higher frequencies of anemia in female are noted. Furthermore, anemia is most commonly seen in the complete type of female patients with Behcet's disease.
[영문] Behcet's disease has been more commonly seen in the Far East(Korea, Japan, China), the Middle East and the Mediterranean area. In the Far East, Behcet's disease occurs more commonly in women than men, However, male predominance is noted in the Mediterranean area, Europe and America. Recently, the study on dietary habits in patients with Behcet's disease in Korea suggest that dietary habits and mineral metabolism are related to geographic differences of male to female ratios. As we know, iron is one of the important factors in cell mediated immunity. The present study was performed to determine the hemoglobin levels, which is associated with iron levels, in our patients with Behcet's disease in relation to clinical types, serum zinc and copper. The followings are the results summarized : 1. Higher frequency of anemia in patients with Behcet's disease(28%) than normal persons(11%) was found. 2. Higher frequency of anemia in female(36%) than male patients(16%) with Behcet's disease was found. 3. There was no statistical significance between frequency of anemia or hemoglobin level and age of patients or duration of Behcet's disease, 4. In adherence to Shimizu's classification, the percentage of anemia found is as follows ; 47%(40 in 85) in the complete type, 29%(65 in 222) in the incomplete type, 19%(26 in 136) in the Suspected type and 16%(12 in 77) in the possible type. 5. In adherence to Lehner's classification, the percentage of anemia found is as fellows ; 67%(54 in 81) in the arthritc type, 57%(4 in 7) in the neurologic type, 34%(41 in 119) in the ocular type and 14%(44 in 313) in the mucocutaneous type. 6. Statistically significant differences in serum zinc levels between the group of patients with anemia(mean serum zinc = 93.5±25.5μg/dl) and without anemia(mean serum zinc = 101.3±26.4μg/dl) were noted. There was a positive correlation between serum zinc levels and hemoglobin levels(regression coefficient = 3.15). 7. Statistically significant differences in serum copper levels between the group of patients with anemia (mean serum copper = 151.2±43.0μg/d1) and without anemia(mean serum copper = 138.1±36.5μg/dl) were noted. There was a negative correlation between serum copper levels and hemoglobin levels (regression coefficient = -6.37). In conclusion, the results of this study suggest that anemia is one of the possible causes of geographic differences of male to female ratios because higher frequencies of anemia in female are noted. Furthermore, anemia is most commonly seen in the complete type of female patients with Behcet's disease.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/117216
Appears in Collections:
2. 학위논문 > 1. College of Medicine (의과대학) > 석사
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