두경부 암환자의 방사선요법시 구강내 캔디다속에 대한 연구

Abstract

[한글]

두경부 악성종양으로 방사선요법을 받는 80명의 환자와 암 연령층인 40∼60세 사이의 정상인 40명을 대조군으로 하여 구강내 캔디다속의 발현과 동정을 조사한 결과 다음과 같은 결론을 얻었다.

1. 대조군 40명중 9명에서 캔디다가 발현되어 22.5%의 발현율을 보였다.

2. 피조사량이 3000R 미만인 환자 26명중 8명에서 캔디다가 발현되어 30.8%의 발현율을 나타냈다.

3. 피조사량이 3000R 이상인 환자 54명중 27명에서 캔디다가 발현되어 50.0%의 발현율을 나타냈다.

4.방사선 치료환자 총 80명중 35명에서 캔디다가 발현되었고 동정실험에서 Candida albicans가 28명, C. tropicalis가 4명, C. krusei와 C. zeylanoids가 각기 1명씩이였고 동정안된 캔디다균종도 1명을 나타냈다.

5. 대조군중 캔디다 발현을 보인 9명의 동정결과는 C. albicans가 5명, C. guilliermondii가 2명, C. parapsilosis와 C. geylanoids가 각기 1 명으로 나타났다.

STUDY OF CANDIDA GENUS ON PATIENTS WITH HEAD AND NECK CANCER DURING RADIOTHERAPY

Shin Jung Cha, D.D.S.

Department of dental Science, The Graduate school, YONSEI UNIVERSITY

(Directed by associated Prof, Eui W, Lee, D.D.S., M.S.D., Ph.D.)

80 cases of head and neck cancer were subjected to oral culture for Candida

species during radiotherapy in Yonsei Cancer Institute and Korea atomic Hospital.

And 40 cases of healthy People were cultured as a control group. Irradiation was

carried out using Co 60 TeleTherapy Units in all patients. Classification of

Candida Genus was done using API 20 Candide Kits.

The results were as follows,

1. Control group was revealed with 22.5 % positive culture of Candida.

2. Positive culture of Candida species on patients irradiated under 3000R was

30.8%.

3. Positive culture of Candida species on patients irradiated over 3000R was 50.0

%.

4. 35 Candida species of eighty irradiated patients were consisted of 28 of C.

albicans, 4 of C. tropicalis, each 1 of C.krusei, C. zeylanoids, and undetermined

Candide sp.

5. Nine Candida species of forty control group were consisted of 5 of Candida

albicans, 2 of C. guilliermondii, each 1 of C. zeylanoids and C. parapsilisis.

[영문]

80 cases of head and neck cancer were subjected to oral culture for Candida species during radiotherapy in Yonsei Cancer Institute and Korea atomic Hospital.

And 40 cases of healthy People were cultured as a control group. Irradiation was carried out using Co 60 TeleTherapy Units in all patients. Classification of Candida Genus was done using API 20 Candide Kits.

The results were as follows,

1. Control group was revealed with 22.5 % positive culture of Candida.

2. Positive culture of Candida species on patients irradiated under 3000R was 30.8%.

3. Positive culture of Candida species on patients irradiated over 3000R was 50.0%.

4. 35 Candida species of eighty irradiated patients were consisted of 28 of C.albicans, 4 of C. tropicalis, each 1 of C.krusei, C. zeylanoids, and undetermined Candide sp.

5. Nine Candida species of forty control group were consisted of 5 of Candida albicans, 2 of C. guilliermondii, each 1 of C. zeylanoids and C. parapsilisis.