교감신경계약물의 개구리피부 Melanophore농축기전(濃縮機轉)에 관한 연구

Abstract

[한글]

THE INFLUENCES OF SYMPATHOMIMETIC AMINES ON MELANOPHORES OF THE FROG SKIN

Chung Koo Cho

Department of Medical Science, The Graduate school, Yonsei University

(Directed by Prof. Tae Ha Woo)

The chromatic activity and potency of various sympathomimetic amines were

examined in the normal frogs using the Hogben and Slome Index as a simple method

for measuring melanophore responses.

All the sympathomimetic amines tested in this experiment exhibited the marked

aggregation of melanophores. Among these amines, the order of potency in producing

the melanophore-aggregation was catecholethylamine derivatives (epinephrine and

isoproterenol) 〉 monohydroxyphenylethylamine derivative (tyramine) with exception

of phenylephrine 〉 nonhydroxyphenylethylamine derivatives (ephedrine and

propadrine). Of catecholethylamine derivatives, the melanophoreaggregating activity

of epinephrine was more potent than that of isoproterenol. One the other hand,

phenylephrine belong to the monodydroxyphenylethylamine derivatives was the least

potent agent that the other amines tested.

[영문]

The chromatic activity and potency of various sympathomimetic amines were examined in the normal frogs using the Hogben and Slome Index as a simple method for measuring melanophore responses.

All the sympathomimetic amines tested in this experiment exhibited the marked aggregation of melanophores. Among these amines, the order of potency in producing the melanophore-aggregation was catecholethylamine derivatives (epinephrine and

isoproterenol) 〉 monohydroxyphenylethylamine derivative (tyramine) with exception of phenylephrine 〉 nonhydroxyphenylethylamine derivatives (ephedrine and

propadrine). Of catecholethylamine derivatives, the melanophoreaggregating activity of epinephrine was more potent than that of isoproterenol. One the other hand,

phenylephrine belong to the monodydroxyphenylethylamine derivatives was the least potent agent that the other amines tested.