난소 절제한 흰쥐에서 골다공증이 하악골에 미치는 영향과 칼시토닌의 예방효과

Abstract

[한글]

전신성 골다공증이 하악골에 나타나는 정도를 관찰하고, 초기의 골다공증에 칼시토닌을 투여시 골다공증이 예방되는 양상을 알아보기 위하여, 흰쥐 암컷중 정상 대조군과 골다공증을 유발시키기 위해 난소를 절제한 군, 그리고 난소절제후 칼시토닌을 투여한 군을

정상 사료로 사육하여 16주 후에 희생시켜 대퇴골과 하악골의 형태계측학적 분석을 통하여 다음과 같은 결과를 얻었다.

1. 대퇴골의 피질골 폭경은 난소절제군에서 대조군보다 감소하였고(p＜0.05) 칼시토닌 투여군에서는 난소절제군보다 증가하였으며(p＜0.05), 피질골 다공도는 난소절제군에서

대조군보다 증가하였고 칼시토닌 투여군에서는 난소절제군보다 감소하였다.

2. 대퇴골의 골양조직과 흡수 소와는 난소절제군에서 대조군보다 증가하였다.

3. 하악골의 피질고 폭경은 난소절제군에서 대조군보다 감소하엿고 칼시토닌 투여군에서는 대조군과 유사하였다.

4. 하악골의 피질골 다공도는 난소절제군과 칼시토닌 투여군에서 대조군보다 감소하였으나, 재고군과 통계학적인 유의차가 없었다(p＞0.05).

5. 하악골의 상대적 소주골부피는 난소절제군에서 대조군보다 감소하였고, 칼시토닌 투여군에서는 대조군보다 약간 감소하였다.

6. 하악골의 골양조직은 난소절제군에서 대조군과 유사하였고, 칼시토닌 투여군에서는 대조군보다 증가하였다.

7. 하악골의 흡수 소와는 난소절제군에서 대조군보다 상당히 증가하였고(p＜0.05), 칼시토닌 투여군에서는 대조군보다 약간 증가하였다(p＜0.05).

흰쥐의 난소절제에 의한 전신성 골다공증은 하악골에도 영향을 미치어 하악골의 피질골과 소주골의 소실이 나타났으며, 칼시토닌은 직접적으로 골흡수를 억제시킴으로써 하악골의 소실을 감소시켜 골다공증의 예방효과를 보여주었고 골형성을 억제시키지 않는 것으로 나타났다.

RELATIONSHIPS BETWEEN THE MANDIBLE AND THE FEMUR IN OSTEOPOROSIS INDUCED BY

OOPHORECTOMY AND EFFECT OF PREVENTIONS BY CALCITONIN IN THE ALBINO RATS

Kyoung Cho, D.D.S., M.S.D.

Dept. of Dental science, Graduate School, Yonsei University

(Directed by Moom-Kyu Chung. D.D.S., M.S.D., Ph. D.)

Osteoporosis, a well known metabolic bone disease, occurs due to imbalance of

bone formings and resorption. In an attempt investigate if postmenopausal

osteoporosis would have influence on the mandible, histomorphometric analysis was

performed in the mandible and the femur of the albino rats. Osteoporosis, was

induced by bilateral oophorectomy. To determine the effect of calcitonin,

calcitonin(Asahi Chemical Co., Japan) was injected in the oophorectomized rats.

The results were as follows:

1. The width of cortical bone of the femur was decreased in the oophorectomized

group compared to the normal control and calcitonin injected groups and the

porosity of cortical bone of the femur was increased in the oophorectomized group

compared to the normal control and calcitonin injected groups.

2. The osteoid tissue and resorption lacuna of the femur was increased in both

oophorectomized and calcitonin groups than the normal control group.

3. The width of cortical bone of the mandible was decreased in the

oophorectomized group compared to the normal control and calcitonin injected

groups.

4. The porosity of cortical bone of the mandible was decreased in both

oophorectomized and calcitonin injected groups than the normal control group.

5. The relative volume of trabecular bone of the mandible was decreased in the

oophorectomized group compared to the normal control and calcitonin injected

groups.

6. The osteoid tissue of the mandible was increased in the calcitonin injected

group than the normal control and oophorectomized groups.

7. The resorption lacuna of the mandible was increased in both oophorectomized

and calcitonin injected groups, particularly in the oophorectomized group.

[영문]

Osteoporosis, a well known metabolic bone disease, occurs due to imbalance of bone formings and resorption. In an attempt investigate if postmenopausal osteoporosis would have influence on the mandible, histomorphometric analysis was performed in the mandible and the femur of the albino rats. Osteoporosis, was

induced by bilateral oophorectomy. To determine the effect of calcitonin, calcitonin(Asahi Chemical Co., Japan) was injected in the oophorectomized rats.

The results were as follows:

1. The width of cortical bone of the femur was decreased in the oophorectomized group compared to the normal control and calcitonin injected groups and the porosity of cortical bone of the femur was increased in the oophorectomized group compared to the normal control and calcitonin injected groups.

2. The osteoid tissue and resorption lacuna of the femur was increased in both oophorectomized and calcitonin groups than the normal control group.

3. The width of cortical bone of the mandible was decreased in the oophorectomized group compared to the normal control and calcitonin injected groups.

4. The porosity of cortical bone of the mandible was decreased in both oophorectomized and calcitonin injected groups than the normal control group.

5. The relative volume of trabecular bone of the mandible was decreased in the oophorectomized group compared to the normal control and calcitonin injected groups.

6. The osteoid tissue of the mandible was increased in the calcitonin injected group than the normal control and oophorectomized groups.

7. The resorption lacuna of the mandible was increased in both oophorectomized and calcitonin injected groups, particularly in the oophorectomized group.