Clinical and histopathological studies on surgical thyroid disease among Koreans
Diseases of the thyroid gland are manifested by either increase in gland size, alterations in hormonal secretion, or both. Changes in gland size and weight are associated with toxic or nontoxic goiter, adenomas, thyroiditis, or malignancies. Most of thyroid disease are menifested by mass, local compression in the neck and symptoms arising from disturbances in hormonogenesis resulting in hypothyroidiam or hyperthyroidism. Also thyroid cancer has nodule and therefore is easily confused as to how to differenciate from other thyroid disease. So that, the thyroid cancer is one of the most debated of all neoplasms in terms of biology, the coruse and growth, precancerous lesions, srugical treatment and prognosis related to histopathological type.
Multiple reports can be found to support almost any thyroid diseases related to malignancy, frequency, etiological factors, age distribution, prognosis and surgical treatment, etc.
There are several reports on thyroid disease including cancer among Koreans based on clinical and statistical aspects, but there is no report of thyroid disease based on histopathological aspects in Korea.
The present studies have surveyed the records of patients with thyroid disorders sean at Severance Hospital from 1960 to 1971. The incidence and pathological classification of all thyroid diseases among Koreans were investigated, and comparison with pathological diagnosis and clinical diagnosis, the incidence of malignancy in cold nodules of scanning, relationship between the malignancy and lymphocytic infiltration and calcification were observed.
Materials and Methods
The materials used in this study cnosist of surgically resected thyroid tissues for 12 years from 1960 to 1971.
All specimins were fixed in 10% formalin. Grossly, the location and size of the tumor were examined. For histologic examinations, paraffin embedded blocks were cut in 5-6u thickness and sections were stained by hematoxylinecsin method.