간경변증환자의 HLA 항원 분포에 관한 연구

Abstract

[한글]

HLA항원계와 각종 질병에 대한 감수성과의 사이에 특이적으로 밀접한 연관성을 가졌으며, 민족이나 종족간에 현저한 차이가 있는 것으로 알려져 있다.

저자는 1982년 4월부터 1982년 8월까지 연세대학교 의과대학 부속 세브란스 병원에 입원하여 B형간염후 발생한 간경변증으로 확진된 42예를 대상으로 HLA-A, B, C loci에 대한 항원분포를 검사하고, 정상대조군 107예와 비교분석하여 다음과 같은 결과를 얻었다.

HLA-A locus는 통계학적으로 유의한 차이가 없었으나, HLA-b locus에서는 B40,B44가 의의있게 간경변증환자에서 증가되었다. HLA-C locus중 Cw3이 증가되었고, Cw4는 정상대조군에 비해 유의한 감소를 보였다.

[영문]

Although HBsAg-positive cirrhosis is caused by hepatitisB virus infection, genetically determined susceptibility to the development of liver cirrhosis has not been excluded.

In looking for such a predisposition, lymphocytes of 42 patients with HBsAg-positive cirrhosis and 107 normal unrelated controls in Korea were examined for histocompatibility antigens(HLA).

The standard two-stage lymphocyte microcytotoxicity method was used to test for 34 antigens: 11 in HLA-A locus, 20 in HLA-B locus, and 3 in HLA-C locus.

The results obtained are as follows:

1. No significant differences of HLA antigens were present at HLA-A locus.

2. The frequencies of HLA-B40 and B44 antigens in patients with liver cirrhosis were increased to 35.7% and 31.0% compared to 10.3% and 5.6% in controls, respectively (P<0.001).

3. The incidence of HLA-Cw3 is significantly greater in patients with liver cirrhosis than in controls and that of HLA-Cw4 is decreased (P<0.05).

In summary, these results showed close association between HBsAg-positive liver cirrhosis and HLA-B locus antigens (B40 and B44). These findings might suggest racial difference.