5. 혈관내피세포는 galaotose에 강반응을, N-acetylglucosamine에 약반응이 나타났으며, 동맥내피세포가 정맥내피세포보다 더 반응이 강하였다.
따라서 이러한 당단백질의 구성을 기초로 하여 향후 여러 가지 인자를 고려한 후각기전에 관한 조직화학적 연구가 필요할 것이라고 사료되었다.
[영문]
In general, olfaction had seemed to be a relatively less significant sense than other senses(vision, hearing, taste, etc.), but it has been becoming a important sense associated with developing economics and cultures.
Many morphological, functional studies on olfactory mucosa have been performed, but immunohistochemistry of olfactory mucosa has not been studied mach so far.
In our study, we used a lectin immunehistochemistry on canine olfactery and respiratory mucosa and the results of distribution of glycoproteins are obtained as follows;
1) In the ciliary layer of olfactory epithelium, mannose, glucose and N-acetylglucosamine showed strong staining reactions.
2) In the olfactory epithelium (such as olfactory cells, sustentaoular cells and basal cells), mannose and N-acetrlglucosamine showed weak staining reactions.
3) In the Bowman's glands, N-acetylglucosamine skewed a strong reaction and mannose, galactose and N-acetylgalactosamine showed weak reactions.
4) In the connective tissue of lamina propria, mannose and galactose showed weak reactions.
5) In the vascular endothelium, galactose showed a strong reaction and N-acetylglucosamine showed a weak reaction. The arterial endothelium skewed the stronger reactions than vein's,
Therefore, we need to do much more immunohistochemical study on the olfactory mucosa for further understanding of olfaction machanism and the roles of glycoprotein contents of olfactory epithelium.