Malignant tumors became to have more and more interest in both for basic
researchers and clinicians, because most inflammatory diseases which had threatened
our livelihood in the past are under control with antibiotics.
Clinically, the neoplastic lesions of the oto-rhino-laryngological field are
detected early for their earlier symptoms and external visibility. Moreover, the
anatomical and histological characteristics such as the thin wall of the paranasal
sinuses with wide continuity, and intimate contact of mucosa or skin to underlying
cartilage on anterior nasal septum, nasal alae, epiglottis and larynx give the
adequate condition to spread the neoplastic lesions early, rapidly and widely. And
other anatomic factors such as: (1) pilosebacious elements of the nares, (2) mucous
gland, abundant vascular tissue, and the nerve elements of nasal cavity, (3) mucous
gland, abundant lymphoid tissue, and possible embryonal remnants in the pharynx,
(4) simple squamous mucosa of oropharynx and tonsils, (5) glands of epiglottis,
larynx, trachea also influenced the special characteristics and peculiar behaviors
of the oto-rhino-laryngeal tumors.
With the development of irradiation therapy and chemotherapy including surgical
technic, there have been great advance of anticancer therapy, and we are highly
expecting to solve this problem as like for anti-inflammatory in a near future. To
solve this problem, it is required to have sound knowledge about clinical and
histopathological characters of the tumors as much as the knowledge of therapeutic
Although a lot of reports have been made public about the tumors of
oto-rhino-laryngological field in Korea and foreign countries, still there have
leaved something to be desired about the general realities and actural condition,
and most of these were confined to only one organ or the period handled the cases
So the auther studied the clinical and histopath logical analysis of tumors of
oto-rhino-laryngological field which were confirmed by biopsy during last twelve
and a half years in Severance hospital.
Materials and Methods.
The materials used in this study consist of biopsy tissues from
oto-rhino-laryngological field under the suspicion of new growth or inflammatory
lesions during last twelve and a half years from Jan. 1960 to Jun. 1972.
All specimens were fixed in 10% formalin, and dehydrated with graded alcohol, and
next embedded in paraffin.
The paraffin embedded blocks were cut in 5-6u thickness and sections were stained
by the Hematoxylin-Eosin method. Clinical analysis including age, sex, chief
complaint and duration of illness were done with available charts.
Histopathological studies on all biopsy cases were performed with the following
Tumors ---+ +-Unclassified +-----Neoplastic ------+----Epithelial
Others(Non pathologic, and insufficient materials)
Results and Summary.
Clinical and histopathological studies were made on 1758 biopsy tissues of
oto-rhino-laryngological lesions which were submitted to the department of
pathology, Yonsei University college of Medicine, during the period of twelve and a
half years from Jan. 1960 to Jun. 1972.
The following results were obtained.
1. Among 1758 cases of biopsy, tumors: 1060(60.3%). inflammations: 639(36.3%),
and others: 59(3.4%). In tumors, benign tumors: 526(47.7%) and malignant tumors:
2. The mean age for benign tumors was 38.1 and for malignant tumors, 52.4. which
showes somewhat earlier tendency to tumor age than foreigners.
3. The male to female ratio were 2.2;1 for benign tumors and 3.2;1 for malignant
tumors, showing male preponderance in both.
4. In the clinical data, hoarseness was the most frequen chief complaint for
laryngeal tumors, nasal obstruction for nasal and paranasal tumors, palpable
cervical mass and nasal obstruction for pharyngeal tumors, and oral and cervical
mass for oral tumors.
5. The duration of illness were less than on year in 60.2% of benign tumors and
83.8% of malignant tumors.
6. The most common histopathological type of benign non-neoplastic tumors was
polyp with the incidence of 89.3% of those.
7. The most common histopathological type of benign neoplastic tumors was
papilloma with the incidence of 53.2% and then in order of frequency was
angiofibroma, hemangioma, and mixed tumor ectc.
8. The most common histopathological type of malignant tumors was squamous cell
carcinoma with the incidence of 69.8% (363/534) and then in order of frequency was
malignant lymphoma, anaplastic carcinoma, basal cell carcinoma etc.
9. The clinical and histopathological analysis for aural lesions was inavailable
because of the data size.