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망상직내피세포계(網狀織內被細胞系)가 고환조직`아렐기 -'성변화에 미치는 영향에 관한 실험적 연구

Other Titles
 Experimental studies on the relationship between the reticuloendothelial system and testicular allergy 
Issue Date
1964
Description
의학과/박사
Abstract
[한글]
[영문] There have been many reports on the relationship between the reticuloendothelial system and allergy but opinions differ among the authors. Owing to many investigators, our knowledge of reticuleothelial system has been expanded, especially as regards to its close relationship to immune bodies. Many investigators disclosed that blockage of reticuloendothelial system with India Ink has inhibiting effect on anaphylactic shock. Some claimed that blockage of reticuloendothelial system with small amount of India Ink enhances an allergic reaction but with large amount of India Ink an allergic reaction is inhibited. But some insisted that blockage of reticuloendothelial system influences on the antibody formation of the system thereby inhibiting allergic reaction. On the other hand, other reticuloendothelial system hormone which is produce by blockage of reticuloendothelial system. Thus there is no clear-cut conclusion as to the exact nature or mode of such effect. The purpose of the present experiments is to study the relationship between the function of the reticuloendothelial system and the allergic inflammation of testis. Materials and Methods Normal rabbits weighing around 2kg, were used. Normal fresh horse serum 1.0c.c. per kg, body weight was subcutaneously injected for 4 consecutive days for sensitization and 0.1c.c. per kg, of body weight was injected into the testicle 2 weeks later. The rabbits were divided into 8 groups as follows; Group 1. control. Group 2. Reticuloendothelial system block with large amount of India Ink before sensitization. Group 3. Reticuloendothelial system block with small amount of India Ink before sensitization. Group 4. Reticuloendothelial system block with large amount of India Ink before reinjection. Group 5. Reticuloendothelial system block with small amount of India Ink before reinjection. Group 6. Normal rabbit serum injection control. Group 7. The rabbit serum injection group and reticuloendothelial system block with large amount of India Ink. Group 8. The rabbit serum injection and reticuloendothelial system block with small amount of India Ink. Results 1. The histologic change of the testicle after reinjection revealed acute inflammation of the testicle with maximum changes occuring at 48 hours after reinjection and the changes subsided gradually. Two weeks after reinjection the changes cleared up except for necrotic foci with leucocytic Infiltration. 2. The 2nd group revealed similar changes with those of the control groups. 3. The allergic changes of the 3rd group were milder than those of the control group. 4. The 4th group showed the allergic changes of the testicle to be definitely milder than those of the control group. 5. The 5th group showed the allergic changes of the testicle to be milder than those of the control group. 6. The 6th group showed the allergic changes of the testicle to be same as those of the normal control group. 7. The 7th group showed the allergic change of the testicle to be definitely milder than those of the control group. 8. The 8th group showed the allergic changes of the testicle to be mildest among any other groups. Conclusions 1. India Ink blockage of the reticuloendothelial system of rabbit has the inhibitory effect on the testicular allergy induced by horse serum. 2. The inhibitory effect on the testicular allergy is not based on the inhibitory effect of the antibody formation by reticuloendothelial system but, on the inhibitory effect of a substance in the rabbit serum, which is produced by reticuloendothelial system blockage with large amount of India Ink. The blockage 2 weeks before reinjection did not appear to produce enough amount of the effective substance which has inhibitory effect on the testicular allergy. 3. The reticuloendothelial system blockage with small amount of India Ink did produce enough amount of the effective substance which has inhibitory effect on the testicular allergy.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/115377
Appears in Collections:
2. 학위논문 > 1. College of Medicine (의과대학) > 박사
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