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인삼이 Adrenaline 투여로서 발생된 각장기의 변화에 미치는 영향에 관한 실험적 연구

Other Titles
 Experimental studies on the effect of Ginseng on the changes of various organs produced by repeated adrenaline injection in the rabbits 
Issue Date
[영문] Early in 1903, Josue called attention on the resemblance of human arteriosclerosis to the lesions he produced in the rabbits by repeated injection of adrenaline through the ear veins. Since that time this method has repeatedly been proven to be one of the most reliable methods of producing aortic lesions experimentally. However, it was later learned that the lesions so produced actually are in the aortic media rather than in the intima which is the usual form of atherosclerosis or arteriosclerosis. Further investigations proved that other substances such as diphtheric toxin, tyramine and other vasotonic subsatnces can also produce similar medial changes as in adrenaline injection. Interests in this field continued since the medial changes were very similar to socalled idiopathic cystic medial necrosis seen in human arota which are often associated with dissecting aneurysm. The interest in the effect of Ginseng continues to attract many investigators since in spite of its advocated curious effects claimed by many people in the orient, there have been very little scientific confirmation of its value to such an extent. Knowing the backgrounds associated with the problem of Ginseng, it was the purpose of this investigator to see the influence of Ginseng on the changes produced by adrenaline injection by means of pathological evaluation. Materials and Methods: Healthy Korean albino rabbits weighing around 2.0Kg. were used. The animals were divided into 5 groups and were treated as follows: Group 1.: 6 animals receiving daily injection of saline into the ear veins for 8 weeks in addition to regular diet. This constituted the control group. Group 2.: 6 animals receiving daily injection of adrenaline into the ear veins for 8 weeks. 0.1 c.c. during the first week and 0.2c.c. during the remainder. Regular diet. Group 3.: 6 animals receiving 2.0gm of Ginseng powder mixed with the diet and daily saline injection for 4 weeks and daily adrenaline injection for 4 weeks thereafter. Group 4.: 6 animals receiving Ginseng powder as well as adrdenaline injection daily for 8 weeks. Group 5.: 6 animals receiving daily adrenaline injection for 4 weeks and Ginseng administration for 4 weeks thereafter. After completion of above experiment all animals were sacrificed and examined grossly. After adequate examination the organs were immediately fixed into 10% neutral formalin and embedded into paraffin. Histological sections were stained with hematoxylin and eosin routinely. Sections from various portions of aorta and heart were stained with phosphotungstic acid hematoxylin, Periordic Acid Schiff reaction, Elastic stain in addition to H. & E. Results and conclusion: The control animals did not show any abnormalities as expected. The adrenaline injection produced profound and devastating damage to the aortic media which were more pronounced in the ascending and thoracic aorta than in the abdominal aorta. The degeneration as it appears to seems affect the muscle fibers earlier and more severely than the other elements of the aorta. Atrophy and loss of muscle fibers created separation of elastic membranes causing cystic changes and later produced strikingly regular but diffuse dissolution of media. Sometimes of calcium salts was present. The animals receiving Ginseng powder with the adrenaline injection also showed some degenerative effects in the media, however, it s extent and severity were far less than seen in the animals receiving adrenaline alone. Adrenaline injection also caused sever panarteritis in the arterioles of myocardium with resultant myocardial damages. None of the animals receiving Ginseneg showed this phenomenon. Arteriolar thickening was also observed int e kidneys in the adrenaline injected animals but not in the other animals. Other minor changes are also described and compared as to their nature and severity. The results obtained in the present investigation strongly suggests that the Ginseng acts favorably for the cure and prevention of diffuse medial degeneration of aorta and other vascular changes in various organs produced by adrenaline injection. It is regrettable that the exact mechanism(s) for such effect can not be adequately presented at this time. Perhaps reported effects of Ginseng in lowering blood pressure might have some connection with such a beneficial effect though it is purely speculative at this time. Further investigation certainly is wanted.
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2. 학위논문 > 1. College of Medicine (의과대학) > 박사
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