Dexamethasone 및 수종약물이 Shope rabbit papilloma에 미치는 영향
Effect of dexamethasone and some drugs on shope rabbit papilloma
In 1933 Shope described an infectious papilloma of wild cottontail rabbits. Shope
rabbit papilloma is a virus-induced epidermal neoplasm indigenous to western
cottontail rabbits and readily transmissible to domestic rabbits by inoculation
with a cell-free extract of wild cottontail papilloma. Shope papilloma induced in
the domestic rabbits may spontaneously, remain benign, or progress to carcinoma.
Kidd et al. (1936) noted that the regression is not correlated with the titer of
virus neutralizing antibody. The possibility that papilloma regression is brought
about by a mechanism analogous to that operating in allograft rejection was
suggested by kidd et al. (1938) with the view of the histological resemblance
between papilloma regression and rejection of allografted tissue. That regression
is mediated by an immu mechanism is strongly indicated by the findings of Evans et
al.(1962) that the proportion of rabbits showing regression is substantially
increased by vaccination of rabbits with rheir own papilloma tissue or with
papilloma tissue from another rabbits.
Mcmichael (1967) demonstrated that suppression of regression was achieved by use
of large doses of corticosteroid.
The effect of 5-fluorouracil on human warts was mentioned as being effective by
Goldman et al.(1963).
In Korea resinous extract from Paulownia coreana has long been used empirically
in the treatment of human warts.
In this investigation effects of dexamethesone administration on the development
and the spontaneous regression of Shope papilloma in domestic rabbits were studied.
At the same time, observations were made to evaluate the comparative
effectiveness of topical application of 5% 5-fluorouracil ointment resinous extract
from Paulownia cireana on Shope papilloma in the domestic rabbits.
The results are summarized as follows :
1. Administration of dexamethasone significantly reduced the spontaneous
regression of Shope papilloma in donestic rabbits by 12 weeks after virus
2. Topical application of 5% 5-fluorouracil ointment on Shope papilloma cured the
tumors by 4 weeks of drug application. However, similar treatment with resinous
extract from Paulownia coreana was without any demonstrable effects.
3. Marked losses of body weight became manifest in dexamethasone treated rabbits.
4. Reinoculation of Shope papilloma virus into 2 rabbits whose papilloma had
regressed 3 months ago failed to produce papillomas.