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Imipramine 및 Lithium이 가토혈중 주정 농도에 미치는 영향에 관한 실험적 연구

Title
 Imipramine 및 Lithium이 가토혈중 주정 농도에 미치는 영향에 관한 실험적 연구 
Other Titles
 Effects of imipramine and lithium on blood alcohol level in rabbits 
Issue Date
1973
Publisher
 연세대학교 대학원 
Description
의학과/석사
Abstract
[한글]
[영문] Imipramine, a tricyclic antidepressant, was synthesized by Hafliger in 1948. Kuhn, in 1958, found imipramine was remarkably effective in certain depressed states, especially in endogenous depression. since then, further evidences for the effectiveness of this compound have been accumulated. Lithium, a monovalent cation and the lightest alkali metal, was discovered in 1818 by Arfwedson. Since Cade, in 1949, found that lithium carbonate caused sedation in guinea pigs and that it did calm manic patients, numerous studies have indicated that the drug is effective in the control of mania and other psychotic excitement and also in prevention of manic depressive episodes. It has lately been reported that lithium and several other psychotropic drugs elevated the blood alcohol level in rabbits. In views of these reports the author conducted an animal experiment to investigate the effects of imipramine and lithium, alone or in combination, on blood alcohol level in rabbits. Materials and Methods 1. The experimental work was done on mature rabbits of both sexes, weighing between 2.0 Kg and 3.0 Kg. 2. The experimental animals were divided into 2 groups; the control and the experimental group. 3. The control group was given alcohol alone. 4. The experimental group was divided into 5 groups; Ⅰ) alcohol + lithium, Ⅱ) alcohol + imipramine (I.M.), Ⅲ) alcohol + lithium + imipramine (I.M.), Ⅳ) alcohol + imipramine(oral), and Ⅴ) alcohol + lithium + imipramine(oral) group. 5. Alcohol + imipramine(I.M.) group was further divided into 4 subgroups, according to the time of alcohol injection; alcohol administration immediately, 10, 20, and 30 minutes after imipramine injection. 6. Alcohol + imipramine(oral) group and alcohol + lithium + imipramine(oral) group were further divided into 2 subgroups in which one subgroup was given imipramine for 7 days and another for 14 days. 7. Lithium chloride solution (6.36%) was given in a dose of 3.0 mEq/Kg of body weight daily for 4 days by intravenous route. The last dose was given 1 hour before alcohol administration. 8. Imipramine was given intramuscularly in a single dose of 2.0 mg/Kg of body weight. In case of oral administration imipramine was given in a dose of 4.0 mg/Kg of body weight daily for 7 days or for 14 days. The last dose was given one hour before alcohol administration. 9. In all groups 20% ethanol solution was given in a dose of 5.0 ml/Kg of body weight in 5 minutes by intravenous route. 10. All of the blood specimens were obtained by cardiac puncture at 10 and 30 minutes after alcohol administration. 11. The blood alcohol level determination was made by Cavett's method. Results 1. Alcohol + lithium group Lithium elevated the blood alcohol level significantly both at 10 and 30 minutes after alcohol administration (P〈0.05). 2. Alcohol + imipramine (I.M.) group Imipramine elevated the blood alcohol level significantly both at 10 and 30 minutes after alcohol administration in the first subgroup in which alcohol was given immediately following imipramine injection (P〈0.05). In the second and third subgroup, the blood alcohol level was elevated significantly only at 10 minutes, but not at 30 minutes after alcohol administration. There was no significant change in the blood alcohol level in the fourth subgroup. 3. Alcohol + lithium + imipramine (I.M.) group Imipramine combined with lithium elevated the blood alcohol level significantly both at 10 and 30 minutes after alcohol administration (P〈0.05). 4. Alcohol + imipramine(oral) group Imipramine elevated the blood alcohol level significantly at 10 and 30 minutes after alcohol administration in the subgroups in which imipramine was administered either for 7 or 14 days (P〈0.05). But there was no significant difference in the blood alcohol level between these two subgroups (P〉0.05). 5. Alcohol + lithium + imipramine(oral) group Imipramine(oral) combined with lithium elevated the blood alcohol level significantly at 10 and 30 minutes after alcohol administration in both subgroups in which imipramine was administered either for 7 or 14 days (P〈0.05). The blood alcohol level of these two subgroups was significantly higher than either that of lithium alone group or imipramine(oral) alone group (P〈0.05). 6. Above experimental results were analysed statistically between the control group and each experimental group, and also among the experimental group. Conclusion 1. The intravenous injection of 6.36% lithium chloride solution in a dose of 3.0 mEq/Kg of body weight daily for 4 days elevated the blood alcohol level in rabbits significantly both at 10 and 30 minutes after alcohol administration. 2. Imipramine administered intramuscularly in a single dose of 2.0 mg/kg of body weight showed variable effects on the blood alcohol level according to the time of alcohol administration after imipramine injection. The blood alcohol level was elevated both at 10 and 30 minutes after alcohol administration in the subgroup in which alcohol was administered immediately after imipramine injection. And in the subgroups in which alcohol was administered at 10 and 20 minutes after imipramine injection, the blood alcohol level was elevated only at 10 minutes after alcohol administration. 3. Imipramine administered orally in a dose of 4.0 mg/kg of body weight daily for 7 or 14 days elevated the blood alcohol level significantly both at 10 and 30 minutes after alcohol administration. There was no significant difference in the blood alcohol level between the two subgroups in which imipramine was administered for 7 or 14 days. 4. Imipramine when combined with lithium elevated the blood alcohol level significantly at 10 and 30 minutes after alcohol administration in both orally and intramuscularly administered groups. In the former group the blood alcohol level was significantly higher than that of imipramine alone or lithium alone group.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/115190
Appears in Collections:
2. 학위논문 > 1. College of Medicine (의과대학) > 석사
Yonsei Authors
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