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Haloperidol 및 Lithium이 가토 혈중 주정 농도에 미치는 영향에 관한 실험적 연구

Title
 Haloperidol 및 Lithium이 가토 혈중 주정 농도에 미치는 영향에 관한 실험적 연구 
Other Titles
 Effects of heloperidol and lithium on blood alcohol level in rabbits 
Issue Date
1974
Publisher
 연세대학교 대학원 
Description
의학과/석사
Abstract
[한글]
[영문]Effects of Heloperidol and Lithium on Blood Alcohol Level in Rabbits Kyung Hi Kim Department of Medical Science, The Graduate School, Yonsei University (Directed by Professor Chae Won Kim, M.D.) Lithium has lately been used in controlling manic excitement, various other psychotic excitements, and recurrence of both manic and depressive symptoms. Haloperidol, synthesized by Janssen, has been introduced for the treatment of psychoses since 1958. It has been verified that haloperidol is a potent, long acting, relatively non-soporific, anti-anxiety and antipsychotic agent and that is relatively non-toxic, and non-addictive. It has been reported that chlorpromazine, lithium and several other psychotropic drugs elevated the blood alcohol level in rabbits. In view of these findings, the author conducted an animal experiment to investigate the effect of haloperidol alone, or in combination with lithium, on blood alcohol level in rabbits. Materials and Method 1. The experimental work was done on mature rabbits of both sexes, weighing between 2.0 and 3.0 kgs. 2. The experiment was done in 2 groups: control and experimental group. 3. Control group was given alcohol alone, and experimental group was further devided into three groups: alcohol + haloperidol group, alcohol + lithium group, and alcohol + haloperidol + lithium group. 4. Haloperidol was given orally. Alcohol + haloperidol group, and alcohol + haloperidol + lithium group were devided into four subgroups. In the first subgroup, haloperidol was given 2 mg/kg of body weight daily for 5 days; in the second subgroup, 2 mg/kg of body weight daily for 10 days; in the third subgroup, 4 mg/kg of body weight daily for 5 days; in the fourth subgroup, 4 mg/kg of body weight daily for 10 days. The last dose of haloperidol was given 90 minutes before alcohol administration. 5. Lithium chloride solution, 6.36%, was given in a dose of 3.0mEq/kg of body weight daily for 4 days by intravenous route. The last dose was given 60 minutes before alcohol administration. 6. In all groups, 20 vol. % ethanol solution was given in a dose of 5.0 ml/kg of body weight, at a constant rate for 5 minutes, by intravenous route. 7. All of the blood specimens were obtained by cardiac puncture at 15 and 45 minutes respectively after alcohol administration. 8. The blood alcohol level was determined by Cavett's method. Results 1. Alcohol + Haloperidol group In both first and second subgroups haloperidol elevated significantly the blood alcohol level in rabbits at 15 minutes after alcohol administration (p〈0.05). But the third and fourth subgroups showed statistically no significant change (p〉0.05). 2. Alcohol + Lithium group Lithium ion elevated the blood alcohol level significantly at both 15 and 45 minutes after alcohol administration (p〈0.05). 3. Alcohol + Haloperidol + Lithium group In both first and third subgroups haloperidol combined with lithium lowered significantly the blood alcohol level at 45 minutes after alcohol administration (p〈0.05). In the second and fourth subgroups the blood alcohol level was lowered significantly at both 15 and 45 minutes after alcohol administration (p〈0.05). Conclusions 1. The orally administered haloperidol, in a dose of 2 mg/kg/day, for 5 and 10 days elevated significantly the blood alcohol level in rabbits at 15 minutes, but not at 45 minutes after alcohol administration. Haloperidol, in a dose of 4 mg/kg/day, for 5 and 10 days had no significant effect on blood alcohol level in rabbits. 2. The intravenous injection of lithium chloride, in a dose of 3.0 mEq/kg/day, for 4 days elevated significantly the blood alcohol level in rabbits at both 15 and 45 minutes after alcohol administration. 3. The haloperidol combined with lithium chloride, in a dose of 2mg/kg/day and 4mg/kg/day respectively for 5 days, lowered significantly the blood alcohol level in rabbits at 45 minutes, but not at 15 minutes after alcohol administration. The haloperidol combined with lithium chloride, when give 2mg/kg/day and 4 mg/kg/day respectively for 10 days, lowered significantly the blood alcohol level in rabbits at both 15 and 45 minutes after alcohol administration.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/115147
Appears in Collections:
2. 학위논문 > 1. College of Medicine (의과대학) > 석사
Yonsei Authors
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