Mycological studies and treatment of tinea pedis with the thiocarbanilide (L-1)
Numerous kinds of fungi are distributed in nature and they have close and complicated relationships with animals and plants in natural circumstances.
Among the fungi, some are quite useful to mankind and some cause diseases in man.
For a long time, many workers have studied on the biological and biochemical characteristics of pathogenic fungi, and diseases caused by them.
Today, superficial fungous infections are widely prevalent throughout the world regardless of human race, and geographic area, and have been recognized as a serious problem all nations.
In spite of the fact that many investigators have developed chemotherapeutic agents for the treatment of superficial, we are still a long way from finding an effective and satisfactory agents.
Kim and Lew(1967) reported that a series of thiocarbanilides have excellent antimycotic actions against various kinds of pathogenic fungi in vitro.
A series of studies was made on clinical trials of L-1, one of the derivatives of thiocarbanilides, for the treatment of Tinea pedis, and on the distribution and classification of causative fungi of Tinea pedis in Korea.
Results and Summary
1. From the 194(35.1 per cent) of the total 520 caces, the causative organisms were isolated. The organisms isolated were T. rubrum from 75 cases(38.3 per cent), T. mentagrophytes from 72 cases(37.1 per cent), E. floccosum from 6 cases(3.0 per cent), Candida species from 21 cases(15.9 per cent), and unclassified fungi from 19 cases(5.7 per cent).
2. For the disappearance of the causative fungi from the skin lesions through the course of the treatment, it took about 4 to 5 weeks in most cases. It appeared more likely that T. rubrum disappeared from the lesion earlier than others through the
treatment, and the disappearance of E. floccosum was slow.
3. L-1 ointment was found to be 90 per cent effective, L-1 solution 80 per cent effective, the oral administration of L-1 capsules 90 per cent effective and the combination of L-1 solution for topical and L-1 capsule for oral administration 100
per cent effective in each treatment group.
It was observed that the combined therapy with L-1 solution and L-1 capsules was more effective than other medicationa. The clinical effectiveness was began from the second week through the treatment. L-1 medications were not effective in the treatment of Candida species of the skin lesions.
4. Most strains of the isolated organisms showed resistance patterns against L-1 by becoming temporarily drug resistant and gradually losing drug-resistance in the continuous subcultures on sabouraud's glucose agar containing of L-1.