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지용성비타민 중독량투여로 인한 내분비선의 변화와 이에 미치는 Cortisone의 영향

Title
 지용성비타민 중독량투여로 인한 내분비선의 변화와 이에 미치는 Cortisone의 영향
Other Titles
 Experimental studies on the effect of cortisone on histological changes of the endocrine glands induced by toxic doses of fat soluble vitamins
Issue Date
1964
Publisher
 연세대학교 대학원
Description
의학과/박사
Abstract
[한글]
[영문] The toxic effects vitamin A caused by ingestion of large quantities of polar bear liver has been reported by Kane in 1857 and by numerous investigators in that field thereafter. The studies on histopathologic changes due to hypervitaminosis A on various organs such as the skeleton, kidney, skin and liver were reported by many workers while Ko(1959) found that hypervitaminosis A brought about degenerative changes of endocrine glands such as pituitary gland, thyroid gland, pancreas, adrenal gland and testicles. In animal experiments, Selye(1958) ascertained that cortisone accelerates skeletal changes produced by vitamin A toxicosis. On the contrary, Fell(1962) indicated that cortisone does not accelerate any pathological changes in the cartilage. On the other hand, Hess(1928) reported vitamin D intoxication in infants treated by ultraviolet irradiated ergosterol and since then many workers have reported hypervitaminosis D or vitamin D sclerosis. In the treatment of vitamin D intoxication, the administration of cortisone produces a marked reduction in the blood concentration of calcium, and an alleviation of various toxic aigns. Dent(1953) observed a reduction in the absorption rate of calcium in the gastrointestinal tract and also a lowered blood calcium concentration by cortisone treatment in the patients of sarcoidosis which was associated with hypercalcemia. Moreover, Thomas and Morgan(1958) noticed an improvement of toxic signs of hypervitaminosis D by the administration of cortisone in animal experiments. Clark and Bassett(1960) described that the weight loss and the calcium deposit in the soft tissue, which were caused by hypervitaminosis D, can be prevented by the administration of large quantities of vitamin A. In view of theses considerations the author attempted to study effects of cortisone on the changes of endocrine glands in hypervitaminosis A, and effects of cortisone on the changes of endocrine glands, induced by a combined administration of toxic dosed of vitamins A and D, in normal rats. 36 rats were subdivided into the following 6 groups, each consisting of 6 animals. Group 1. This group is the control group, consisting of rats fed on stock diet and 500 I.U. of vitamin A/gm of body weight/day by stomach tubing for 3 weeks. Group 2. This group is also the control group, consisting of rats fed on stock diet and 60 I.U. of vitamin d/gm of body weight/day by stomach tubing for 3 weeks. Group 3. This group consisted of rats which were fed on a stock diet and, in addition, received orally 60 I.U. of vitamin D/gm of body weight/day and also 500 I.U. of vitamin A/gm of body weight/day for 3 weeks. Group 4. This group consisted of rats which were fed on stock diet and, in addition, given 0.05mg of cortisone acetate/gm of body weight/day(I.M.) for 3 weeks. Group 5. This group was placed on the same regimen as Group 1. In addition, 0.05mg of cortisone acetate/gm of body weight/day was intramuscularly administered for 3 weeks. Group 6. This group was placed for 3 weeks on the same regimen as Group 3 and, in addition, 0.05mg cortisone acetate/gm of body weight/day for 3 weeks. At the end of 3 week experimental period, the rats were sacrificed by injecting air into the heart. According to these experiments, the changes on the anterior pituitary gland induced by administration of toxic doses of vitamin A were relatively mild; the nuclear pyknosis of acidophilic cells including slight changes in basophilic cells were observed while cortisone affected more remarkable to the above changes. The degenerative changes of the thyroid gland due to the administration of toxic doses of vitamin A were aggravated by cortisone adminstration, and the outstanding change to be noted were desquamation of acinar cells and nuclear pyknosis. Main pancreatic changes induced by toxic doses of vitamin A were atrophy of ductal cells. Cortisone administration resulted in hypertrophy of Langerhan's islet and a considerably severe atrophy of ductal cells in general. Changes of the adrenal gland produced by toxic doses of vitamin A were a slight hypertrophy in zona faciculata and hyperemia in the medulla. These changes became more remarkable administration of cortisone. Changes in the testis with the toxic doses of vitamin A were atrophy of seminiferous duct, proliferation of Sertoli's cell followed by degenerative changes and slight proliferative changes in stroma. These changes also became more marked by the cortisone administration. Changes on the anterior pituitary gland caused by a combined administration of toxic doses of vitamins A and D were very mild as compared to those seen when vitamin A alone was given. When cortisone was additionally given, moderate to severe changes in basophilic cells and a clear-cut vaculization of the cell were found. Effects on the thyroid gland were again milder in case of a combined vitamin A and D administration than in administration of vitamin A alone. In the pancreas, only a slight condensation of ductal cells and zymogen granulations have been observed in the groups of toxic doses of vitamin A and D. In contrast, a high incidence of acinar cell desquamation was observed when vitamin A alone was given. Pancreatic changes induced by a combined administration of vitamins A and D were a mild degree of condensation of ductal cells and a reduction in zymogen granulation; these changes were considerably milder than those seen when vitamin A alone was given. Changes induced by cortisone were pyknosis of ductal cells and a slight hypertrophy of Langerhan's islet. Toxic doses of vitamin A and D induced a very mild change on the adrenal gland. Severe degenerative changes in zona glomeruloza and zona faciculata have been observed by cortisone administration. Testicle changes induced by toxic doses of vitamins A and D were degeneration of the seminiferous duct, proliferation and hyperemia of interstitial cells. These changes were more prominent when cortisone is administered; a reduction in sperm formation, degeneration of the seminiferous duct and proliferation of the sertoli's interstitial cell were observed. These results indicate that cortisone aggravates while vitamin D alleviates morphological changes of various endocrine glands, induced by a toxic dose of vitamin A, although both cortisone and vitamin D themselves induce morphological changes of endocrine glands. However, the underlying mechanism(s) for these interesting effects are not clear at present.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/115051
Appears in Collections:
2. 학위논문 > 1. College of Medicine (의과대학) > 박사
Yonsei Authors
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