Cited 11 times in
Combined Treatment of an Intratumoral Injection of Dendritic Cells and Systemic Chemotherapy (Paclitaxel) for Murine Fibrosarcoma
DC Field | Value | Language |
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dc.contributor.author | 이민걸 | - |
dc.contributor.author | 이홍식 | - |
dc.date.accessioned | 2015-08-26T16:41:56Z | - |
dc.date.available | 2015-08-26T16:41:56Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/114929 | - |
dc.description.abstract | A novel combined treatment of conventional chemotherapy with an intratumoral injection of syngeneic dendritic cells (DCs) has emerged as a potent cancer treatment strategy. In this study, we evaluated the synergistic effect of an intraperitoneal (i.p.) injection of a chemotherapeutic drug, paclitaxel, and an intratumoral (i.t.) injection of syngeneic bone marrow-derived DCs for the treatment of pre-existing fibrosarcoma. Subcutaneous tumors were established using MCA102 fibrosarcoma cells in syngeneic C57BL/6 mice. The results demonstrated that the combined treatment of paclitaxel chemotherapy and the injection of DCs led to complete tumor regression, in contrast to only partial eradication of the tumors with chemotherapy or DCs alone. Furthermore, the tumor-free mice were able to resist a repeat challenge with the same type of tumor. These findings suggest that a combination therapy of systemic chemotherapy along with the intratumoral administration of DCs is a potent treatment strategy for fibrosarcoma. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 835~842 | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Antineoplastic Agents, Phytogenic/administration & dosage | - |
dc.subject.MESH | Antineoplastic Agents, Phytogenic/therapeutic use* | - |
dc.subject.MESH | Bone Marrow Cells/cytology | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Cells, Cultured | - |
dc.subject.MESH | Combined Modality Therapy | - |
dc.subject.MESH | Dendritic Cells/cytology | - |
dc.subject.MESH | Dendritic Cells/transplantation* | - |
dc.subject.MESH | Fibrosarcoma/drug therapy | - |
dc.subject.MESH | Fibrosarcoma/pathology | - |
dc.subject.MESH | Fibrosarcoma/therapy* | - |
dc.subject.MESH | Immunologic Memory | - |
dc.subject.MESH | Injections, Intraperitoneal | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Paclitaxel/administration & dosage | - |
dc.subject.MESH | Paclitaxel/therapeutic use* | - |
dc.subject.MESH | Phenotype | - |
dc.subject.MESH | Transplantation, Isogeneic | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Combined Treatment of an Intratumoral Injection of Dendritic Cells and Systemic Chemotherapy (Paclitaxel) for Murine Fibrosarcoma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Dermatology (피부과학) | - |
dc.contributor.googleauthor | Gwang-Seong Choi | - |
dc.contributor.googleauthor | Moon-Hee Lee | - |
dc.contributor.googleauthor | Sun U. Song | - |
dc.contributor.googleauthor | Min-Geol Lee | - |
dc.contributor.googleauthor | Woo-Chul Kim | - |
dc.contributor.googleauthor | Jong-Rok Lee | - |
dc.contributor.googleauthor | Do-Hwan Seong | - |
dc.contributor.googleauthor | Hye-Yun Kil | - |
dc.contributor.googleauthor | Moon-Whan Im | - |
dc.contributor.googleauthor | Hong-Sik Lee | - |
dc.contributor.googleauthor | Chul-Soo Kim | - |
dc.contributor.googleauthor | Soon-Ki Kim | - |
dc.identifier.doi | 10.3349/ymj.2005.46.6.835 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02779 | - |
dc.contributor.localId | A03332 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 16385661 | - |
dc.subject.keyword | Dendritic cells | - |
dc.subject.keyword | paclitaxel | - |
dc.subject.keyword | immunotherapy | - |
dc.contributor.alternativeName | Lee, Min Geol | - |
dc.contributor.alternativeName | Lee, Hong Shick | - |
dc.contributor.affiliatedAuthor | Lee, Min Geol | - |
dc.contributor.affiliatedAuthor | Lee, Hong Shick | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 46 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 835 | - |
dc.citation.endPage | 842 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.46(6) : 835-842, 2005 | - |
dc.identifier.rimsid | 39317 | - |
dc.type.rims | ART | - |
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