Cited 34 times in
Anaplastic thyroid carcinoma: A therapeutic dilemma
DC Field | Value | Language |
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dc.contributor.author | 남기현 | - |
dc.contributor.author | 박정수 | - |
dc.contributor.author | 장항석 | - |
dc.contributor.author | 정웅윤 | - |
dc.date.accessioned | 2015-08-26T16:39:20Z | - |
dc.date.available | 2015-08-26T16:39:20Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/114856 | - |
dc.description.abstract | Anaplastic thyroid carcinoma (ATC) is one of the most malignant human neoplasms and has a grave prognosis. This study gives an update on our experience with this unusual neoplasm, with specific focus on the response to various treatment modalities. Forty-seven patients with histologically proven ATCs were enrolled (19 men, 28 women; mean age, 62.8 years). This number represents 1.5% among a total of 3,088 thyroid cancers treated between 1977 and 2002. The mean tumor diameter was 8.8 cm, and 22 patients had distant metastasis. Extrathyroidal extension was seen in 26 (89.7%) of the cases that underwent surgery. Treatment modalities adopted could be classified into 5 groups: Group 1, biopsy only; Group 2, biopsy and chemoradiotherapy; Group 3, debulking only; Goup 4, debulking and chemoradiotherapy; Group 5, complete excision and chemoradiotherapy. Survival was calculated from the time of diagnosis, and comparisons of survival were done by log-rank analysis. The mean survival was 4.3 months (range, 1.0-21 months). The mean survival based on treatment modalities were as follows: Group 1 (n = 10), 2.1 months, Group 2 (n = 8); 3.6 months; Group 3 (n = 7), 3.0 months; Group 4 (n = 14), 3.5 months, Group 5 (n = 8), 9.4 months. There was no significant difference in survival time between the various types of treatment modalities. Even though a small improvement in survival was observed with complete excision and aggressive multimodality therapy, nearly all ATCs remain unresponsive to ongoing treatment modalities and as such, present a therapeutic dilemma. A more effective treatment regimen should be sought in order to improve survival. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 759~764 | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Carcinoma/mortality | - |
dc.subject.MESH | Carcinoma/surgery | - |
dc.subject.MESH | Carcinoma/therapy* | - |
dc.subject.MESH | Chemotherapy, Adjuvant | - |
dc.subject.MESH | Combined Modality Therapy | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Metastasis | - |
dc.subject.MESH | Radiotherapy, Adjuvant | - |
dc.subject.MESH | Survival Analysis | - |
dc.subject.MESH | Thyroid Neoplasms/mortality | - |
dc.subject.MESH | Thyroid Neoplasms/surgery | - |
dc.subject.MESH | Thyroid Neoplasms/therapy* | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Anaplastic thyroid carcinoma: A therapeutic dilemma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학) | - |
dc.contributor.googleauthor | Hang-Seok Chang | - |
dc.contributor.googleauthor | Kee-Hyun Nam | - |
dc.contributor.googleauthor | Cheong Soo Park | - |
dc.contributor.googleauthor | Woung Youn Chung | - |
dc.identifier.doi | 10.3349/ymj.2005.46.6.759 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01646 | - |
dc.contributor.localId | A01245 | - |
dc.contributor.localId | A03488 | - |
dc.contributor.localId | A03674 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 16385650 | - |
dc.subject.keyword | Anaplastic thyroid cancer | - |
dc.subject.keyword | treatment modalities | - |
dc.subject.keyword | treatment outcome | - |
dc.contributor.alternativeName | Nam, Kee Hyun | - |
dc.contributor.alternativeName | Park, Cheong Soo | - |
dc.contributor.alternativeName | Chang, Hang Seok | - |
dc.contributor.alternativeName | Chung, Woung Youn | - |
dc.contributor.affiliatedAuthor | Park, Cheong Soo | - |
dc.contributor.affiliatedAuthor | Nam, Kee Hyun | - |
dc.contributor.affiliatedAuthor | Chang, Hang Seok | - |
dc.contributor.affiliatedAuthor | Chung, Woung Youn | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 46 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 759 | - |
dc.citation.endPage | 764 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.46(6) : 759-764, 2005 | - |
dc.identifier.rimsid | 38521 | - |
dc.type.rims | ART | - |
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