Cited 103 times in
Acute Hemodynamic Effects of Octreotide and Terlipressin in Patients with Cirrhosis: A Randomized Comparison
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이동기 | - |
dc.date.accessioned | 2015-08-26T16:36:38Z | - |
dc.date.available | 2015-08-26T16:36:38Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 0002-9270 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/114785 | - |
dc.description.abstract | BACKGROUND: Octreotide and terlipressin are widely used in acute variceal hemorrhage to reduce the bleeding rate. They purportedly act by mesenteric arterial vasoconstriction, thus reducing portal venous flow (PVF) and portal pressure. Little is known about the immediate-early hemodynamic effects of these drugs. AIM: To compare the acute hemodynamic effects of octreotide and terlipressin in patients with cirrhosis. PATIENTS: Forty-two cirrhotic patients with a history of variceal bleeding were randomized to receive either octreotide 100 microg intravenous bolus followed by a continuous infusion at 250 microg/h (n = 21), or terlipressin 2 mg intravenous bolus (n = 21). METHODS: Mean arterial pressure (MAP), heart rate (HR), hepatic venous pressure gradient (HVPG), and PVF, assessed by duplex Doppler ultrasonography, were measured before and at 1, 5, 10, 15, 20, and 25 min after the start of drug administration. RESULTS: Octreotide markedly decreased HVPG (-44.5 +/- 17.8%) and PVF (-30.6 +/- 13.6%) compared to the baseline at 1 min (p < 0.05). Thereafter, both variables rapidly returned toward the baseline, and by 5 min, no significant differences in HVPG (-7.1 +/- 28.9%) and PVF (10.2 +/- 26.2%) were noted. A similar transient effect on MAP and HR was observed. Terlipressin significantly decreased HVPG (-18.3 +/- 11.9%) and PVF (-32.6 +/- 10.5%) at 1 min (p < 0.05) and sustained these effects at all time points. The effects on arterial pressure and HR were also sustained. CONCLUSIONS: Octreotide only transiently reduced portal pressure and flow, whereas the effects of terlipressin were sustained. These results suggest that terlipressin may have more sustained hemodynamic effects in patients with bleeding varices. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 631~635 | - |
dc.relation.isPartOf | AMERICAN JOURNAL OF GASTROENTEROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Blood Pressure/drug effects | - |
dc.subject.MESH | Esophageal and Gastric Varices/drug therapy* | - |
dc.subject.MESH | Esophageal and Gastric Varices/physiopathology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gastrointestinal Agents/administration & dosage | - |
dc.subject.MESH | Gastrointestinal Agents/pharmacology* | - |
dc.subject.MESH | Heart Rate/drug effects | - |
dc.subject.MESH | Hemodynamics/drug effects* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Injections, Intravenous | - |
dc.subject.MESH | Liver Circulation/drug effects | - |
dc.subject.MESH | Liver Cirrhosis/drug therapy* | - |
dc.subject.MESH | Liver Cirrhosis/physiopathology | - |
dc.subject.MESH | Lypressin/administration & dosage | - |
dc.subject.MESH | Lypressin/analogs & derivatives* | - |
dc.subject.MESH | Lypressin/pharmacology* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Octreotide/administration & dosage | - |
dc.subject.MESH | Octreotide/pharmacology* | - |
dc.subject.MESH | Portal System/drug effects | - |
dc.subject.MESH | Terlipressin | - |
dc.subject.MESH | Ultrasonography, Doppler, Duplex | - |
dc.subject.MESH | Vasoconstrictor Agents/administration & dosage | - |
dc.subject.MESH | Vasoconstrictor Agents/pharmacology* | - |
dc.subject.MESH | Venous Pressure/drug effects | - |
dc.title | Acute Hemodynamic Effects of Octreotide and Terlipressin in Patients with Cirrhosis: A Randomized Comparison | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Soon Koo Baik | - |
dc.contributor.googleauthor | Phil Ho Jeong | - |
dc.contributor.googleauthor | Samuel S Lee | - |
dc.contributor.googleauthor | Sei Jin Chang | - |
dc.contributor.googleauthor | Joong Wha Park | - |
dc.contributor.googleauthor | Young Ju Kim | - |
dc.contributor.googleauthor | Sang Ok Kwon | - |
dc.contributor.googleauthor | Dong Ki Lee | - |
dc.contributor.googleauthor | Hyun Soo Kim | - |
dc.contributor.googleauthor | Byung Su Yoo | - |
dc.contributor.googleauthor | Sang Won Ji | - |
dc.identifier.doi | 10.1111/j.1572-0241.2005.41381.x | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02723 | - |
dc.relation.journalcode | J00081 | - |
dc.identifier.eissn | 1572-0241 | - |
dc.identifier.pmid | 15743362 | - |
dc.identifier.url | http://www.nature.com/ajg/journal/v100/n3/full/ajg2005107a.html | - |
dc.subject.keyword | 15743362 | - |
dc.contributor.alternativeName | Lee, Dong Ki | - |
dc.contributor.affiliatedAuthor | Lee, Dong Ki | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 100 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 631 | - |
dc.citation.endPage | 635 | - |
dc.identifier.bibliographicCitation | AMERICAN JOURNAL OF GASTROENTEROLOGY, Vol.100(3) : 631-635, 2005 | - |
dc.identifier.rimsid | 38473 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.