Cited 29 times in
Use of NSE/PS2m-transgenic mice in the study of the protective effect of exercise on Alzheimer's disease
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 남기택 | - |
dc.date.accessioned | 2015-07-15T17:20:00Z | - |
dc.date.available | 2015-07-15T17:20:00Z | - |
dc.date.issued | 2003 | - |
dc.identifier.issn | 0264-0414 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/114694 | - |
dc.description.abstract | In its late stage, Alzheimer's disease results in progressive muscle weakness in the arms and legs. The aim of this study was to determine whether mice expressing the skeletal muscle-specific mutant PS2 gene (a model of Alzheimer's disease) are a useful experimental system to study the protective effect of exercise on Aβ-42 reduction, improvement of behavioural function and changes in metabolic parameters. With this aim in mind, the transgenic mice were subjected to treadmill exercise for 3 months. The results showed that in transgenic mice, but not in normal mice, treadmill exercise resulted in a reduction of Aβ-42 deposits and an improvement in behavioural function, thereby restoring normal concentrations of total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and triglyceride. Thus, exercise may represent a practical therapeutic strategy for use with human patients with Alzheimer's disease. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 943~951 | - |
dc.relation.isPartOf | JOURNAL OF SPORTS SCIENCES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Alzheimer Disease/genetics* | - |
dc.subject.MESH | Alzheimer Disease/metabolism* | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Behavior, Animal/physiology | - |
dc.subject.MESH | Blotting, Western | - |
dc.subject.MESH | Brain/metabolism | - |
dc.subject.MESH | Cholesterol/blood | - |
dc.subject.MESH | Cholesterol, HDL/blood | - |
dc.subject.MESH | Cholesterol, LDL/blood | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Maze Learning/physiology | - |
dc.subject.MESH | Membrane Proteins/genetics* | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Transgenic | - |
dc.subject.MESH | Muscle, Skeletal/metabolism | - |
dc.subject.MESH | Phosphopyruvate Hydratase/genetics* | - |
dc.subject.MESH | Physical Conditioning, Animal/physiology* | - |
dc.subject.MESH | Presenilin-2 | - |
dc.subject.MESH | Reverse Transcriptase Polymerase Chain Reaction | - |
dc.subject.MESH | Triglycerides/blood | - |
dc.title | Use of NSE/PS2m-transgenic mice in the study of the protective effect of exercise on Alzheimer's disease | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Life Science (의생명과학부) | - |
dc.contributor.googleauthor | Jun Y Cho | - |
dc.contributor.googleauthor | Dae Y Hwang | - |
dc.contributor.googleauthor | Yong K Kim | - |
dc.contributor.googleauthor | Jung S Cho | - |
dc.contributor.googleauthor | Kyu S Lee | - |
dc.contributor.googleauthor | Ki T Nam | - |
dc.contributor.googleauthor | Youn S Song | - |
dc.contributor.googleauthor | Su J Seo | - |
dc.contributor.googleauthor | Sae H Min | - |
dc.contributor.googleauthor | Hwa J Lim | - |
dc.contributor.googleauthor | Su H Lee | - |
dc.contributor.googleauthor | Chae H Lim | - |
dc.contributor.googleauthor | Jin H Hwang | - |
dc.contributor.googleauthor | Dong H Shin | - |
dc.contributor.googleauthor | Tae S Kang | - |
dc.identifier.doi | 10.1080/0264041031000140365 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01243 | - |
dc.relation.journalcode | J01756 | - |
dc.identifier.eissn | 1466-447X | - |
dc.identifier.pmid | 14626374 | - |
dc.identifier.url | http://www.tandfonline.com/doi/abs/10.1080/0264041031000140365#.U84aN6izIyo | - |
dc.subject.keyword | Alzheimer's disease | - |
dc.subject.keyword | cholesterol | - |
dc.subject.keyword | exercise | - |
dc.subject.keyword | presenilin | - |
dc.subject.keyword | sports | - |
dc.subject.keyword | transgenic | - |
dc.contributor.alternativeName | Nam, Ki Taek | - |
dc.contributor.affiliatedAuthor | Nam, Ki Taek | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 21 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 943 | - |
dc.citation.endPage | 951 | - |
dc.identifier.bibliographicCitation | JOURNAL OF SPORTS SCIENCES, Vol.21(11) : 943-951, 2003 | - |
dc.identifier.rimsid | 46066 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.