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한국인 성인의 High Sensitive C-reactive Protein 농도와 경동맥 내중막두께

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dc.contributor.author안철우-
dc.contributor.author차봉수-
dc.date.accessioned2015-07-15T17:11:31Z-
dc.date.available2015-07-15T17:11:31Z-
dc.date.issued2003-
dc.identifier.issn1015-6461-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/114413-
dc.description.abstractBackground: A chronic inflammatory response is an important component in the development and progression of atherosclerosis. Since the development of the high-sensitive C-reactive protein (hs-CRP) assay, the association between subtle increases in the hs-CRP concentration and the development of atherosclerosis, has recently been reported. In this study, the relationship between hs-CRP, conventional cardiovascular risk factors and carotid intima media thickness (IMT), were investigated, and whether hs-CRP concentrations analyzed to see if it could be used as an independent risk factor, of early subclinical atherosclerosis in apparently healthy subjects. Methods: This report was conducted as part of the Korean Metabolic Syndrome Study. Of 1,230 individuals having undergone a routine check-up, 849 were selected, based on their medical history of cardiovascular diseases. The hs-CRP was measured by an ELISA method, using human anti-CRP (CRP II Latex X2, Denka Seiken, Japan). Results: The distribution of the hs-CRP concentration was positively skewed, and the hs-CRP levels ranged from 0.10 to 43.7 mg/L (mean 2.06, median 0.77 mg/L). There were significant positive correlations between the hs-CRP and age, BMI, waist, BP, insulin resistance (HOMA-IR) and the TC/HDL-C ratio. From a multiple regression analysis, independent relationships between the hs-CRP and obesity, hypertension, age ( 60 years), current smoking, male and insulin resistance were found. There were positive correlations between the carotid IMT and age, BMI, waist circumference, SBP, DBP, TC, TG, LDL-C, fasting blood glucose, HOMA-IR and hs-CRP, and a negative correlation between the carotid IMT and the HDL-C. From the multiple regression analysis, independent relationships between the carotid IMT and age, SBP, TC/HDLc, HOMA-IR, waist circumference, and DBP also persisted. After adjusting for the conventional risk factors in the multiple regression, there was no longer a significant relationship between the hs-CRP and the carotid IMT. Conclusion: There were strong correlations between the hs-CRP and the conventional cardiovascular risk factors, especially with that of obesity. Also, a highly significant association was also found between the hs-CRP and the carotid IMT. However, the hs-CRP, per se, is not a major independent risk factor of early subclinical atherosclerosis in Koreans.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.relation.isPartOfJournal of Korean Diabetes Association (당뇨병)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHHigh sensitive C-reactive protein-
dc.subject.MESHIntima media thickness-
dc.subject.MESHAtherosclerosis-
dc.subject.MESHInflammation-
dc.title한국인 성인의 High Sensitive C-reactive Protein 농도와 경동맥 내중막두께-
dc.title.alternativeHigh Sensitive C-reactive Protein and Carotid Intima Media Thickness in Korean Population-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthor김대중-
dc.contributor.googleauthor최성희-
dc.contributor.googleauthor허갑범-
dc.contributor.googleauthor이현철-
dc.contributor.googleauthor김경래-
dc.contributor.googleauthor임승길-
dc.contributor.googleauthor송영득-
dc.contributor.googleauthor차봉수-
dc.contributor.googleauthor안철우-
dc.contributor.googleauthor정상수-
dc.contributor.googleauthor김세화-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02270-
dc.contributor.localIdA03996-
dc.relation.journalcodeJ01508-
dc.subject.keywordHigh sensitive C-reactive protein-
dc.subject.keywordIntima media thickness-
dc.subject.keywordAtherosclerosis-
dc.subject.keywordInflammation-
dc.contributor.alternativeNameAhn, Chul Woo-
dc.contributor.alternativeNameCha, Bong Soo-
dc.contributor.affiliatedAuthorAhn, Chul Woo-
dc.contributor.affiliatedAuthorCha, Bong Soo-
dc.rights.accessRightsfree-
dc.citation.volume27-
dc.citation.number1-
dc.citation.startPage49-
dc.citation.endPage62-
dc.identifier.bibliographicCitationJournal of Korean Diabetes Association (당뇨병), Vol.27(1) : 49-62, 2003-
dc.identifier.rimsid47289-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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