Cited 8 times in
B-Type Natriuretic Peptide Predicts Clinical Presentations and Ventricular Overloading in Patients with Heart Failure
DC Field | Value | Language |
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dc.contributor.author | 김정호 | - |
dc.contributor.author | 정보영 | - |
dc.contributor.author | 홍범기 | - |
dc.date.accessioned | 2015-07-15T16:51:41Z | - |
dc.date.available | 2015-07-15T16:51:41Z | - |
dc.date.issued | 2003 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/113743 | - |
dc.description.abstract | Brain natriuretic peptide (BNP), a neurohormone secreted from the ventricular myocardium in response to hemodynamic load/wall stress, in congestive heart failure (CHF). This study was performed to evaluate the correlation between BNP level and clinical presentations and hemodynamic parameters obtained by echo-Doppler (echo-Doppler) analysis, and its relation with disease severity and ventricular load/wall stress. CHF patients (n=246) were subgrouped by clinical presentations and echo-Doppler findings into 4 groups: diastolic HF only, chronic HF, acute HF, and chronic HF with acute exacerbation. A BNP level of 81.2 pg/ml showed a sensitivity/specificity of 53.3%/98.4% for detecting CHF (AUC, 0.882; p < 0.0001), and was found to be closely related with the NYHA classification (p < 0.0001). Log BNP was related with LVEF (r2=0.3015, p < 0.0001) and the Meridional wall stress index (r2=0.4052, p < 0.0001). The difference between the BNP levels of the subgroups and BNP control was significant (p < 0.0001), exept between the HF group and the controls; control (n=114, 20.9 ± 31.4pg/ml), only diastolic HF (n=84, 89.8 ± 117.6pg/ml), chronic HF (n=60, 208.2 ± 210.2pg/ml), acute HF (n=28, 477.9 ± 498.4 pg/ml), chronic HF with acute exacerbation (n= 74, 754.1 ± 419.2pg/ml). The BNP level was significantly higher in the only diastolic HF group than in the asymptomatic control group with diastolic dysfunction (89.8 ± 12.8 vs. 22.8 ± 5.1pg/ml, p < 0.0001). BNP may be a good indicator for the differential diagnosis of a broad spectrum of heart failures. And, elevated BNP might help to diagnose diastolic HF in patients with diastolic dysfunction. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Atrial Natriuretic Factor/blood* | - |
dc.subject.MESH | Echocardiography | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Heart Failure/blood* | - |
dc.subject.MESH | Heart Failure/complications* | - |
dc.subject.MESH | Heart Failure/diagnostic imaging | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Natriuretic Peptide, Brain | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Ventricular Dysfunction/etiology* | - |
dc.title | B-Type Natriuretic Peptide Predicts Clinical Presentations and Ventricular Overloading in Patients with Heart Failure | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Bo Young Joung | - |
dc.contributor.googleauthor | Byung Eun Park | - |
dc.contributor.googleauthor | Hyuck Moon Kwon | - |
dc.contributor.googleauthor | Jeong Ho Kim | - |
dc.contributor.googleauthor | Hyun Seung Kim | - |
dc.contributor.googleauthor | Young Won Yoon | - |
dc.contributor.googleauthor | Sang Hak Lee | - |
dc.contributor.googleauthor | Yun Hyeong Cho | - |
dc.contributor.googleauthor | Dong Yeon Kim | - |
dc.contributor.googleauthor | Bum Kee Hong | - |
dc.contributor.googleauthor | Dong Soo Kim | - |
dc.identifier.doi | 10.3349/ymj.2003.44.4.623 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00903 | - |
dc.contributor.localId | A03609 | - |
dc.contributor.localId | A00260 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 12950118 | - |
dc.subject.keyword | B type natriuretic peptide | - |
dc.subject.keyword | congestive heart failure | - |
dc.subject.keyword | myocardial wall stress | - |
dc.contributor.alternativeName | Kim, Jeong Ho | - |
dc.contributor.alternativeName | Joung, Bo Young | - |
dc.contributor.affiliatedAuthor | Kim, Jeong Ho | - |
dc.contributor.affiliatedAuthor | Joung, Bo Young | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 44 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 623 | - |
dc.citation.endPage | 634 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.44(4) : 623-634, 2003 | - |
dc.identifier.rimsid | 49061 | - |
dc.type.rims | ART | - |
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