Cited 31 times in
Calreticulin inhibits the MEK1,2-ERK1,2 pathway in alpha 1-adrenergic receptor/Gh-stimulated hypertrophy of neonatal rat cardiomyocytes.
DC Field | Value | Language |
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dc.contributor.author | 이경희 | - |
dc.contributor.author | 임소연 | - |
dc.contributor.author | 장양수 | - |
dc.contributor.author | 고영국 | - |
dc.date.accessioned | 2015-07-15T16:37:37Z | - |
dc.date.available | 2015-07-15T16:37:37Z | - |
dc.date.issued | 2003 | - |
dc.identifier.issn | 0960-0760 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/113275 | - |
dc.description.abstract | In cardiac myocytes, stimulation of α1-adrenoceptor (AR) leads to a hypertrophic phenotype. The Gh protein (transglutaminase II, TGII) is tissue type transglutaminase and transmits the α1B-adrenoceptor signal with GTPase activity. Recently, it has been shown that the calreticulin (CRT) down-regulates both GTP binding and transglutaminase activities of TGII. To elucidate whether Gh mediates norepinephrine-stimulated intracellular signal transductions leading to activation of extracellular signal-regulated kinases (ERKs) and neonatal rat cardiomyocyte hypertrophy, we examined the effects of Gh on the activation of ERKs and inhibitory effects of CRT on α1-adrenoceptor/Gh signaling. In neonatal rat cardiomyocytes, norepinephrine-induced ERKs activation was inhibited by an α1-adrenoceptor blocker (prazosin), but not by an β-adrenoceptor blocker (propranolol). Overexpression of the Gh protein stimulated norepinephrine-induced ERKs activation, which was inhibited by α-adrenoceptor blocker (prazosin). Co-overexpression of Gh and CRT abolished norepinephrine-induced ERKs activation. Taken together, norepinephrine induces hypertrophy in neonatal rat cardiomyocytes through α1-AR stimulation and Gh is partly involved in norepinephrine-induced MEK1,2/ERKs activation. Activation of Gh-mediated MEK1,2/ERKs was completely inhibited by CRT. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 101~107 | - |
dc.relation.isPartOf | JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Neonatal rat cardiomyocyte | - |
dc.subject.MESH | Hypertrophy | - |
dc.subject.MESH | ERKs | - |
dc.subject.MESH | Gh | - |
dc.subject.MESH | Calreticulin | - |
dc.title | Calreticulin inhibits the MEK1,2-ERK1,2 pathway in alpha 1-adrenergic receptor/Gh-stimulated hypertrophy of neonatal rat cardiomyocytes. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Physiology (생리학) | - |
dc.contributor.googleauthor | Namho Lee | - |
dc.contributor.googleauthor | Soyeon Lim | - |
dc.contributor.googleauthor | Kyung-Hye Lee | - |
dc.contributor.googleauthor | Heekyung Jung | - |
dc.contributor.googleauthor | Young-Guk Ko | - |
dc.contributor.googleauthor | Hyun-Young Park | - |
dc.contributor.googleauthor | Yangsoo Jang | - |
dc.contributor.googleauthor | Hakbae Lee | - |
dc.contributor.googleauthor | Ki-Chul Hwang | - |
dc.identifier.doi | 10.1016/S0960-0760(03)00006-2 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03448 | - |
dc.contributor.localId | A00127 | - |
dc.contributor.localId | A02662 | - |
dc.contributor.localId | A03373-1 | - |
dc.relation.journalcode | J01757 | - |
dc.identifier.eissn | 1879-1220 | - |
dc.identifier.pmid | 10.1016/S0960-0760(03)00006-2 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0960076003000062 | - |
dc.subject.keyword | Neonatal rat cardiomyocyte | - |
dc.subject.keyword | Hypertrophy | - |
dc.subject.keyword | ERKs | - |
dc.subject.keyword | Gh | - |
dc.subject.keyword | Calreticulin | - |
dc.contributor.alternativeName | Lee, Kyung Hee | - |
dc.contributor.alternativeName | Lim, So Yeon | - |
dc.contributor.alternativeName | Jang, Yang Soo | - |
dc.contributor.alternativeName | Ko, Young Guk | - |
dc.contributor.affiliatedAuthor | Jang, Yang Soo | - |
dc.contributor.affiliatedAuthor | Ko, Young Guk | - |
dc.contributor.affiliatedAuthor | Lee, Kyung Hee | - |
dc.contributor.affiliatedAuthor | Lim, So Yeon | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 84 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 101 | - |
dc.citation.endPage | 107 | - |
dc.identifier.bibliographicCitation | JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, Vol.84(1) : 101-107, 2003 | - |
dc.identifier.rimsid | 55794 | - |
dc.type.rims | ART | - |
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