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Adoptive Immunotherapy for Cytomegalovirus (CMV) Disease in Immunocompromised Patients
DC Field | Value | Language |
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dc.contributor.author | 권오헌 | - |
dc.contributor.author | 김현숙 | - |
dc.contributor.author | 김현옥 | - |
dc.contributor.author | 임종백 | - |
dc.contributor.author | 최종락 | - |
dc.date.accessioned | 2015-07-14T17:13:00Z | - |
dc.date.available | 2015-07-14T17:13:00Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/112438 | - |
dc.description.abstract | Cytomegalovirus (CMV) reactivation in immune compromised patients such as those undergoing hematopoietic progenitor cell transplantation (HPCT) and those with HIV infections can cause severe morbidity and mortality despite treatment with appropriate antiviral agents. The recovery of Cytomegalovirus (CMV) specific cytotoxic T lymphocytes (CTL) plays an important role in the reconstitution of CMV specific immunity in immunocompromised patients. Recent studies have reported that CMV reactivation can be successfully treated by adoptive transfer of CMV-specific T cell clones from CMV seropositive donors expanded in vitro with CMV infected fibroblasts or lysates of CMV infected cells. Other studies have used immune dominant CMV proteins or peptides to expand CMV-specific cytotoxic T lymphocytes. This review describes the clinical manifestations of CMV disease in immunocompromised patients, recent advances of antiviral therapy for CMV disease, the principals of the induction of cellular immune response to CMV, and the clinical application of CMV immunotherapy. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | S18~S22 | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Cytomegalovirus Infections/immunology* | - |
dc.subject.MESH | Cytomegalovirus Infections/therapy* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunocompromised Host* | - |
dc.subject.MESH | Immunotherapy, Adoptive* | - |
dc.title | Adoptive Immunotherapy for Cytomegalovirus (CMV) Disease in Immunocompromised Patients | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학) | - |
dc.contributor.googleauthor | Jong Baeck Lim | - |
dc.contributor.googleauthor | Oh Hun Kwon | - |
dc.contributor.googleauthor | David Stroncek | - |
dc.contributor.googleauthor | Maurizio Provenzano | - |
dc.contributor.googleauthor | Jong Rak Choi | - |
dc.contributor.googleauthor | Hyun Ok Kim | - |
dc.contributor.googleauthor | Hyon Suk Kim | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 15250045 | - |
dc.contributor.alternativeName | Kwon, Oh Hun | - |
dc.contributor.alternativeName | Kim, Hyon Suk | - |
dc.contributor.alternativeName | Kim, Hyun Ok | - |
dc.contributor.alternativeName | Lim, Jong Baeck | - |
dc.contributor.alternativeName | Choi, Jong Rak | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 45 | - |
dc.citation.number | Suppl. | - |
dc.citation.startPage | 18 | - |
dc.citation.endPage | 22 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.45(Suppl.) : 18-22, 2004 | - |
dc.identifier.rimsid | 56172 | - |
dc.type.rims | ART | - |
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