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비만하지 않은 한국인 성인 제2형 당뇨병 환자의 항GAD 항체 양성률과 항체 유무에 따른 임상적, 생화학적 특성
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김똘미 | - |
dc.contributor.author | 김철식 | - |
dc.contributor.author | 남주영 | - |
dc.contributor.author | 박종숙 | - |
dc.contributor.author | 박진아 | - |
dc.contributor.author | 안철우 | - |
dc.contributor.author | 이현철 | - |
dc.contributor.author | 임승길 | - |
dc.contributor.author | 차봉수 | - |
dc.contributor.author | 김경래 | - |
dc.date.accessioned | 2015-07-14T16:59:55Z | - |
dc.date.available | 2015-07-14T16:59:55Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 1015-6461 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/112003 | - |
dc.description.abstract | Background: Some of the characteristic features of diabetes mellitus in Korea are that 70-80% of patients are non-obese or adult-onset type, and type 1 diabetes is very rare. Occasionally, autoantibodies to glutamic acid decarboxylase(GAD) are found in typical, type 2 diabetes mellitus patients(T2DM). The role of the autoantibody to GAD in T2DM is unknown. The aim of this study was to determine the clinical and biochemical characteristics between GAD-positive and GAD-negative non-obese, adult-onset diabetics in Korea. Methods: A cohort of 428 type 2 diabetes patients was included. The measured autoantibodies to GAD were measured, and the C-peptide and HbA1c levels, anthropometric data(weight, height, body mass index and waist circumference), blood pressure and lipid profiles compared between the two groups. Results: Compared to the antibody-negative group(n=374; 87.4%), patients with the anti-GAD antibody(n=54; 12.6%) had significantly lower C-peptide levels and were significantly younger. The anti GAD-positive group had a lower BMI, more frequently needed insulin supplements, and a lower prevalence of hypertension. There were no significant differences in gender and family history of diabetes between the two groups. Conclusion: The presence of the autoantibody to GAD allowed the group with more deteriorated beta-cell function and more frequent need for insulin supplements, but a lower prevalence of obesity and hypertension to be determined. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 66~74 | - |
dc.relation.isPartOf | Journal of Korean Diabetes Association (당뇨병) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 비만하지 않은 한국인 성인 제2형 당뇨병 환자의 항GAD 항체 양성률과 항체 유무에 따른 임상적, 생화학적 특성 | - |
dc.title.alternative | The Frequency of Anti-GAD Antibody in Non-obese, Adult-onset Type 2 Diabetes in Korea and Clinical and Biological Characteristics According to Anti-GAD Antibody | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | 김철식 | - |
dc.contributor.googleauthor | 박진아 | - |
dc.contributor.googleauthor | 이현철 | - |
dc.contributor.googleauthor | 김경래 | - |
dc.contributor.googleauthor | 임승길 | - |
dc.contributor.googleauthor | 차봉수 | - |
dc.contributor.googleauthor | 암철우 | - |
dc.contributor.googleauthor | 김똘미 | - |
dc.contributor.googleauthor | 남주영 | - |
dc.contributor.googleauthor | 박종숙 | - |
dc.contributor.googleauthor | 조민호 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.relation.journalcode | J01508 | - |
dc.subject.keyword | Alcohol drinking problems | - |
dc.subject.keyword | Diabetes self-care | - |
dc.subject.keyword | Male diabetics | - |
dc.contributor.alternativeName | Kim, Dol Mi | - |
dc.contributor.alternativeName | Kim, Chul Sik | - |
dc.contributor.alternativeName | Nam, Ju Young | - |
dc.contributor.alternativeName | Park, Jong Suk | - |
dc.contributor.alternativeName | Park, Jina | - |
dc.contributor.alternativeName | Ahn, Chul Woo | - |
dc.contributor.alternativeName | Lee, Hyun Chul | - |
dc.contributor.alternativeName | Lim, Sung Kil | - |
dc.contributor.alternativeName | Cha, Bong Soo | - |
dc.contributor.alternativeName | Kim, Kyung Rae | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 28 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 66 | - |
dc.citation.endPage | 74 | - |
dc.identifier.bibliographicCitation | Journal of Korean Diabetes Association (당뇨병), Vol.28(2) : 66-74, 2004 | - |
dc.identifier.rimsid | 53573 | - |
dc.type.rims | ART | - |
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