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미분화 갑상선암: 치료적 딜레마
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박정수 | - |
dc.contributor.author | 윤정호 | - |
dc.contributor.author | 장항석 | - |
dc.contributor.author | 정웅윤 | - |
dc.date.accessioned | 2015-07-14T16:58:38Z | - |
dc.date.available | 2015-07-14T16:58:38Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 1226-0053 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/111961 | - |
dc.description.abstract | Purpose: Anaplastic thyroid carcinoma (ATC) is one of the most malignant human neoplasm, with a grave prognosis. This study updates our experience with this unusual neoplasm with specific focus on the response to various treatment modalities. Methods: Forty-seven patients with histologically proven ATC were enrolled (19 men, 28 women; mean age, 62.8 years). This group represented 1.5% of the 3,088 thyroid cancers treated between 1977 to 2002. The mean diameter of tumor was 8.8 cm (range, 2.0∼20.0 cm), and 22 patients had distant metastasis (10 in the lung, 8 lung and bone, 1 brain, 1 mediastinum, and 2 lung and mediastinum). Extrathyroidal extension was seen in 26 (89.7%) of the cases that underwent surgery. Treatment modalities adopted were classified into 5 groups. Group 1, biopsy only; group 2, biopsy and chemoradiotherapy; group 3, debulking only; group 4 debulking and chemoradiotherapy; and group 5, complete excision and chemoradiotherapy. Survival was calculated from the time of diagnosis, and comparisons of survival were done by log-rank analysis. Results: The mean survival was 4.3 months (range, 1.0∼21 months). The mean survival bases of treatment modalities were as follows: group 1 (n=10), 2.1 months (range 1.0∼6.0); group 2 (n=8), 3.6 months (range, 2.0∼7.0 months); group 3 (n=7), 3.0 months (range, 1.0∼11.0 months); group 4 (n=14), 3.5 months (range, 2.0∼9.0 months), group 5 (n=8), 9.4 months (range 5.0∼21.0 months). Conclusion: Even though a small improvement of survival in response was observed with complete excision and aggressive multimodality therapy, nearly all ATC remains ineffective to ongoing treatment modalities and continue to present a therapeutic dilemma. A more effective treatment regimen should be sought for improving the survival rate. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 14~19 | - |
dc.publisher | 대한외과학회 | - |
dc.relation.isPartOf | JOURNAL OF THE KOREAN SURGICAL SOCIETY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 미분화 갑상선암: 치료적 딜레마 | - |
dc.title.alternative | Treatment of Anaplastic Thyroid Carcinoma: A Therapeutic Dilemma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학) | - |
dc.contributor.googleauthor | 장항석 | - |
dc.contributor.googleauthor | 윤종호 | - |
dc.contributor.googleauthor | 박정수 | - |
dc.contributor.googleauthor | 정웅윤 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.relation.journalcode | J01893 | - |
dc.subject.keyword | Anaplastic thyroid cancer | - |
dc.subject.keyword | Treatment modalities | - |
dc.subject.keyword | Treatment outcome | - |
dc.subject.keyword | 미분화 갑상선암 | - |
dc.subject.keyword | 치료방법 | - |
dc.subject.keyword | 치료결과 | - |
dc.contributor.alternativeName | Park, Cheong Soo | - |
dc.contributor.alternativeName | Yoon, Jong Ho | - |
dc.contributor.alternativeName | Chang, Hang Seok | - |
dc.contributor.alternativeName | Chung, Woung Youn | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 66 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 14 | - |
dc.citation.endPage | 19 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE KOREAN SURGICAL SOCIETY , Vol.66(1) : 14-19, 2004 | - |
dc.identifier.rimsid | 53539 | - |
dc.type.rims | ART | - |
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