Cited 0 times in
과민성 장증후군 환자에서 세로토닌 수송단백질 유전자의 다형성과 혈중 세로토닌치간의 연관 관계
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김영균 | - |
dc.contributor.author | 박효진 | - |
dc.contributor.author | 이상인 | - |
dc.contributor.author | 지상원 | - |
dc.date.accessioned | 2015-07-14T16:54:23Z | - |
dc.date.available | 2015-07-14T16:54:23Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 1226-5608 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/111821 | - |
dc.description.abstract | Background/Aims: Serotonin is an important mediator of intestinal peristalsis and it undergoes reuptake by a transporter protein (SERT). It has been reported that polymorphisms in the promoter for synthesis of SERT (SERT-P) influence the response to a serotonin reuptake inhibitor and a serotonin receptor antagonist. The aim of this study was to investigate gene polymorphism in the SERT-P in healthy adults and patients with irritable bowel syndrome (IBS) and a plasma serotonin level according to genetic polymorphism. Methods: SERT gene polymorphism was assessed by polymerase chain reaction on DNA chains in serum samples from 53 patients with IBS and 56 healthy adults. The platelet-depleted plasma serotonin level of a fasting state was quantitatively measured by ELISA. Results: There was no significant difference in the allele frequency between the IBS and the control group, and according to the subtypes of IBS patients. The platelet-depleted plasma serotonin level was significantly higher in IBS patients than in controls (P<0.05). However, there was no significant difference in the plasma serotonin level according to the subtypes of IBS or genetic polymorphism of SERT-P. Conclusions: SERT-P is not a key factor in determining the development of IBS in Korea. Patients with IBS have significantly higher fasting plasma serotonin levels than controls, irrespective of genetic polymorphism at SERT-P. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 125~129 | - |
dc.relation.isPartOf | Korean Journal of Neurogastroenterology and Motility (대한소화관운동학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 과민성 장증후군 환자에서 세로토닌 수송단백질 유전자의 다형성과 혈중 세로토닌치간의 연관 관계 | - |
dc.title.alternative | Serotonin Transporter Gene Polymorphism and its Relationship to Plasma Serotonin in Irritable Bowel Syndrome | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | 박효진 | - |
dc.contributor.googleauthor | 이덕용 | - |
dc.contributor.googleauthor | 이상인 | - |
dc.contributor.googleauthor | 지상원 | - |
dc.contributor.googleauthor | 김영균 | - |
dc.contributor.googleauthor | 최은주 | - |
dc.contributor.googleauthor | 김민수 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.relation.journalcode | J02067 | - |
dc.subject.keyword | Irritable bowel syndrome | - |
dc.subject.keyword | Serotonin | - |
dc.subject.keyword | Serotonin transporter protein | - |
dc.contributor.alternativeName | Kim, Young Gyun | - |
dc.contributor.alternativeName | Park, Hyo Jin | - |
dc.contributor.alternativeName | Lee, Sang In | - |
dc.contributor.alternativeName | Ji, Sang Won | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 10 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 125 | - |
dc.citation.endPage | 129 | - |
dc.identifier.bibliographicCitation | Korean Journal of Neurogastroenterology and Motility (대한소화관운동학회지), Vol.10(2) : 125-129, 2004 | - |
dc.identifier.rimsid | 47307 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.