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건강한 성인 및 과민성 장 증후군 환자에서 세로토닌 수송 단백질 유전자의 다형성
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이상인 | - |
dc.contributor.author | 최영철 | - |
dc.contributor.author | 김원호 | - |
dc.contributor.author | 박효진 | - |
dc.date.accessioned | 2015-07-14T16:53:13Z | - |
dc.date.available | 2015-07-14T16:53:13Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 1598-9992 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/111784 | - |
dc.description.abstract | Background/Aims: Serotonin is thought to be an important neurotransmitter in the pathogenesis of irritable bowel syndrome (IBS). It is reported that functional polymorphism in the promotor region of the serotonin transporter gene is related with the subtypes of IBS and shows racial difference. However, a functional relation between polymorphism and IBS is not clear. The aim of this study was to investigate 5-hydroxytryptamine transporter (5-HTT) gene polymorphism in patients with IBS. Methods: For fifty-six healthy controls and 33 patients with IBS fulfilling Rome II criteria, 5`-flank promotor region of 5-HTT gene was analyzed by polymerase chain reaction. Results: The genotypes of healthy controls were S/S (57.1%), S/L (37.5%), and L/L (5.4%). Those of IBS patients were S/S (54.5%), S/L (36.4%), and L/L (9.1%). IBS patients were divided into three groups: diarrhea predominant (n=15; S/S, 40%; S/L, 53.3%; L/L, 6.7%), constipation predominant (n=12; S/S, 75.0%; S/L, 8.3%; L/L, 16.7%), diarrhea-constipation alternating type (n=6; S/S, 50%; S/L, 50%). There was no statistical difference in the 5-HTT gene polymorphism between patients and controls, and according to the subtypes of IBS patients (p=0.135). Conclusions: There was no relationship between serotonin transporter gene polymorphism and IBS. However, allele S/S genotype was most prominent genotype in both controls and patients. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 18~22 | - |
dc.language | Korean Journal of Gastroenterology | - |
dc.publisher | Korean Journal of Gastroenterology | - |
dc.relation.isPartOf | Korean Journal of Gastroenterology | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Irritable Bowel Syndrome/genetics* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Membrane Glycoproteins/genetics* | - |
dc.subject.MESH | Membrane Transport Proteins/genetics* | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Nerve Tissue Proteins/genetics* | - |
dc.subject.MESH | Polymorphism, Genetic* | - |
dc.subject.MESH | Serotonin/genetics | - |
dc.subject.MESH | Serotonin Plasma Membrane Transport Proteins | - |
dc.title | 건강한 성인 및 과민성 장 증후군 환자에서 세로토닌 수송 단백질 유전자의 다형성 | - |
dc.title.alternative | Serotonin Transporter Gene Polymorphism in Healthy Adults and Patients with Irritable Bowel Syndrome | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurology (신경과학) | - |
dc.contributor.googleauthor | 이덕용 | - |
dc.contributor.googleauthor | 박효진 | - |
dc.contributor.googleauthor | 최영철 | - |
dc.contributor.googleauthor | 서윤주 | - |
dc.contributor.googleauthor | 이상인 | - |
dc.contributor.googleauthor | 김원호 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.relation.journalcode | J02015 | - |
dc.identifier.eissn | 2233-6869 | - |
dc.identifier.pmid | 14745247 | - |
dc.subject.keyword | Serotonin | - |
dc.subject.keyword | Serotonin transporter | - |
dc.subject.keyword | Irritable bowel syndrome | - |
dc.contributor.alternativeName | Lee, Sang In | - |
dc.contributor.alternativeName | Choi, Young Chul | - |
dc.contributor.alternativeName | Kim, Won Ho | - |
dc.contributor.alternativeName | Park, Hyo Jin | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 43 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 18 | - |
dc.citation.endPage | 22 | - |
dc.identifier.bibliographicCitation | Korean Journal of Gastroenterology, Vol.43(1) : 18-22, 2004 | - |
dc.identifier.rimsid | 37466 | - |
dc.type.rims | ART | - |
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