Cited 21 times in
The pattern of gene copy number changes in bilateral breast cancer surveyed by cDNA microarray-based comparative genomic hybridization.
DC Field | Value | Language |
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dc.contributor.author | 라선영 | - |
dc.contributor.author | 박병우 | - |
dc.contributor.author | 박찬희 | - |
dc.contributor.author | 서민영 | - |
dc.contributor.author | 안중배 | - |
dc.contributor.author | 양상화 | - |
dc.contributor.author | 양우익 | - |
dc.contributor.author | 이귀연 | - |
dc.contributor.author | 정현철 | - |
dc.date.accessioned | 2015-07-14T16:51:24Z | - |
dc.date.available | 2015-07-14T16:51:24Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 1107-3756 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/111726 | - |
dc.description.abstract | The nature of genetic alterations in bilateral breast cancer (BBC) associated with the distinctive development of a second primary tumor or a metastatic lesion is not clearly established. In this study, patterns of promoter methylation and gene copy number changes were assessed for their utility in the distinction of two types of BBC (synchronous and metachronous). Seven cases of synchronous and five cases of metachronous breast cancer tissues were used in X chromosome inactivation assay to assess the methylation pattern of human androgen receptor gene. X chromosome inactivation assay alone did not provide enough information to distinguish the genetic origins of synchronous and metachronous BBC. When four pairs of paraffin-embedded BBC tissues were used in cDNA array-based CGH with placenta DNA as a reference, higher DNA copy number changes were observed from metachronous pairs (9.0%) than from synchronous pairs (3.1%). From the two cases of metachronous pairs tested, 44 genes were found to be commonly modulated in gene copy numbers in a cancer detected later. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 17~24 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Breast Neoplasms/genetics* | - |
dc.subject.MESH | Chromosomes, Human, X* | - |
dc.subject.MESH | DNA, Complementary | - |
dc.subject.MESH | Dosage Compensation, Genetic | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gene Dosage* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Nucleic Acid Hybridization | - |
dc.subject.MESH | Oligonucleotide Array Sequence Analysis | - |
dc.title | The pattern of gene copy number changes in bilateral breast cancer surveyed by cDNA microarray-based comparative genomic hybridization. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Min Young Seo | - |
dc.contributor.googleauthor | Sun Young Rha | - |
dc.contributor.googleauthor | Hyun Cheol Chung | - |
dc.contributor.googleauthor | Byung Woo Park | - |
dc.contributor.googleauthor | Joong Bae Ahn | - |
dc.contributor.googleauthor | Woo Ick Yang | - |
dc.contributor.googleauthor | Chan Hee Park | - |
dc.contributor.googleauthor | Gui Youn Lee | - |
dc.contributor.googleauthor | Sang Cheol Kim | - |
dc.contributor.googleauthor | Sang Hwa Yang | - |
dc.identifier.doi | 10.3892/ijmm.13.1.17 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.relation.journalcode | J01132 | - |
dc.identifier.eissn | 1791-244X | - |
dc.identifier.pmid | 14654965 | - |
dc.identifier.url | http://www.spandidos-publications.com/ijmm/13/1/17 | - |
dc.contributor.alternativeName | Rha, Sun Young | - |
dc.contributor.alternativeName | Park, Byeong Woo | - |
dc.contributor.alternativeName | Park, Chan Hee | - |
dc.contributor.alternativeName | Seo, Min Young | - |
dc.contributor.alternativeName | Ahn, Joong Bae | - |
dc.contributor.alternativeName | Yang, Sang Hwa | - |
dc.contributor.alternativeName | Yang, Woo Ick | - |
dc.contributor.alternativeName | Lee, Gui Youn | - |
dc.contributor.alternativeName | Chung, Hyun Cheol | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 13 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 17 | - |
dc.citation.endPage | 24 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, Vol.13(1) : 17-24, 2004 | - |
dc.identifier.rimsid | 37435 | - |
dc.type.rims | ART | - |
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